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Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial

PURPOSE: To examine the effects of Ginkgo biloba extract EGb 761(®) on neuropsychiatric symptoms of dementia. PATIENTS AND METHODS: Randomized, controlled, double-blind, multicenter clinical trial involving 410 outpatients with mild to moderate dementia (Alzheimer’s disease with or without cerebrova...

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Autores principales: Bachinskaya, Natalia, Hoerr, Robert, Ihl, Ralf
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090284/
https://www.ncbi.nlm.nih.gov/pubmed/21573082
http://dx.doi.org/10.2147/NDT.S18741
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author Bachinskaya, Natalia
Hoerr, Robert
Ihl, Ralf
author_facet Bachinskaya, Natalia
Hoerr, Robert
Ihl, Ralf
author_sort Bachinskaya, Natalia
collection PubMed
description PURPOSE: To examine the effects of Ginkgo biloba extract EGb 761(®) on neuropsychiatric symptoms of dementia. PATIENTS AND METHODS: Randomized, controlled, double-blind, multicenter clinical trial involving 410 outpatients with mild to moderate dementia (Alzheimer’s disease with or without cerebrovascular disease, vascular dementia), scoring at least 5 on the Neuropsychiatric Inventory (NPI), with at least one item score of 3 or more. Total scores on the SKT cognitive test battery (Erzigkeit’s short syndrome test) were between 9 and 23. After random allocation, the patients took 240 mg of EGb 761(®) or placebo once daily for a period of 24 weeks. Changes from baseline to week 24 in the NPI composite and in the SKT total score were the primary outcomes. The NPI distress score was chosen as a secondary outcome measure to evaluate caregivers’ distress. RESULTS: The NPI composite score improved by −3.2 (95% confidence interval −4.0 to −2.3) in patients taking EGb 761(®) (n = 202), but did not change (−0.9; 0.9) in those receiving placebo (n = 202), which resulted in a statistically significant difference in favor of EGb 761(®) (P < 0.001). Treatment with EGb 761(®) was significantly superior to placebo for the symptoms apathy/indifference, sleep/night-time behavior, irritability/lability, depression/dysphoria, and aberrant motor behavior. Caregivers’ distress evaluation revealed similar baseline pattern and improvements. CONCLUSION: Treatment with EGb 761(®), at a once-daily dose of 240 mg, was safe, effectively alleviated behavioral and neuropsychiatric symptoms in patients with mild to moderate dementia, and improved the wellbeing of their caregivers.
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spelling pubmed-30902842011-05-13 Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial Bachinskaya, Natalia Hoerr, Robert Ihl, Ralf Neuropsychiatr Dis Treat Original Research PURPOSE: To examine the effects of Ginkgo biloba extract EGb 761(®) on neuropsychiatric symptoms of dementia. PATIENTS AND METHODS: Randomized, controlled, double-blind, multicenter clinical trial involving 410 outpatients with mild to moderate dementia (Alzheimer’s disease with or without cerebrovascular disease, vascular dementia), scoring at least 5 on the Neuropsychiatric Inventory (NPI), with at least one item score of 3 or more. Total scores on the SKT cognitive test battery (Erzigkeit’s short syndrome test) were between 9 and 23. After random allocation, the patients took 240 mg of EGb 761(®) or placebo once daily for a period of 24 weeks. Changes from baseline to week 24 in the NPI composite and in the SKT total score were the primary outcomes. The NPI distress score was chosen as a secondary outcome measure to evaluate caregivers’ distress. RESULTS: The NPI composite score improved by −3.2 (95% confidence interval −4.0 to −2.3) in patients taking EGb 761(®) (n = 202), but did not change (−0.9; 0.9) in those receiving placebo (n = 202), which resulted in a statistically significant difference in favor of EGb 761(®) (P < 0.001). Treatment with EGb 761(®) was significantly superior to placebo for the symptoms apathy/indifference, sleep/night-time behavior, irritability/lability, depression/dysphoria, and aberrant motor behavior. Caregivers’ distress evaluation revealed similar baseline pattern and improvements. CONCLUSION: Treatment with EGb 761(®), at a once-daily dose of 240 mg, was safe, effectively alleviated behavioral and neuropsychiatric symptoms in patients with mild to moderate dementia, and improved the wellbeing of their caregivers. Dove Medical Press 2011 2011-04-20 /pmc/articles/PMC3090284/ /pubmed/21573082 http://dx.doi.org/10.2147/NDT.S18741 Text en © 2011 Bachinskaya et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Bachinskaya, Natalia
Hoerr, Robert
Ihl, Ralf
Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title_full Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title_fullStr Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title_full_unstemmed Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title_short Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761(®). Findings from a randomized controlled trial
title_sort alleviating neuropsychiatric symptoms in dementia: the effects of ginkgo biloba extract egb 761(®). findings from a randomized controlled trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090284/
https://www.ncbi.nlm.nih.gov/pubmed/21573082
http://dx.doi.org/10.2147/NDT.S18741
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