Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation

BACKGROUND: Apoptosis, neuroinflammation and blood-brain barrier (BBB) damage affect the susceptibility of the developing brain to hypoxic-ischemic (HI) insults. c-Jun N-terminal kinase (JNK) is an important mediator of insulin resistance in obesity. We hypothesized that neonatal overweight aggravat...

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Detalles Bibliográficos
Autores principales: Tu, Yi-Fang, Tsai, Yau-Sheng, Wang, Lan-Wan, Wu, Hsin-Chieh, Huang, Chao-Ching, Ho, Chien-Jung
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090337/
https://www.ncbi.nlm.nih.gov/pubmed/21518436
http://dx.doi.org/10.1186/1742-2094-8-40

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