Defective CFTR-Dependent CREB Activation Results in Impaired Spermatogenesis and Azoospermia

Cystic fibrosis (CF) is the most common life-limiting recessive genetic disease among Caucasians caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) with over 95% male patients infertile. However, whether CFTR mutations could affect spermatogenesis and result in azo...

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Detalles Bibliográficos
Autores principales: Xu, Wen Ming, Chen, Jing, Chen, Hui, Diao, Rui Ying, Fok, Kin Lam, Dong, Jian Da, Sun, Ting Ting, Chen, Wen Ying, Yu, Mei Kuen, Zhang, Xiao Hu, Tsang, Lai Ling, Lau, Ann, Shi, Qi Xian, Shi, Qing Hua, Huang, Ping Bo, Chan, Hsiao Chang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090391/
https://www.ncbi.nlm.nih.gov/pubmed/21625623
http://dx.doi.org/10.1371/journal.pone.0019120

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