Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress

Glutathione (GSH) is a major player in cellular defense against oxidative stress. Deletion of the modifier subunit of glutamate cysteine ligase (GCLM), the first and the rate-limiting enzyme in the synthesis of GSH, leads to significantly lower GSH levels in all tissues including the brain. GCLM-kno...

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Detalles Bibliográficos
Autores principales: Cole, Toby B., Giordano, Gennaro, Co, Aila L., Mohar, Isaac, Kavanagh, Terrance J., Costa, Lucio G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090610/
https://www.ncbi.nlm.nih.gov/pubmed/21559092
http://dx.doi.org/10.1155/2011/157687

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