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Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult

Visceral leishmaniasis is characterized by fever, cachexia, hepatosplenomegaly, pancytopenia, and hypergammaglobulinemia. Cough may be a presenting symptom as well. However, pulmonary involvement is considered rare and mainly described in immunocompromised patients. We describe a case of an immunoco...

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Autores principales: Kotsifas, Konstantinos, Metaxas, Eugenios, Koutsouvelis, Ioannis, Skoutelis, Athanassios, Kara, Panayiota, Tatsis, George
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090634/
https://www.ncbi.nlm.nih.gov/pubmed/21577261
http://dx.doi.org/10.1155/2011/561985
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author Kotsifas, Konstantinos
Metaxas, Eugenios
Koutsouvelis, Ioannis
Skoutelis, Athanassios
Kara, Panayiota
Tatsis, George
author_facet Kotsifas, Konstantinos
Metaxas, Eugenios
Koutsouvelis, Ioannis
Skoutelis, Athanassios
Kara, Panayiota
Tatsis, George
author_sort Kotsifas, Konstantinos
collection PubMed
description Visceral leishmaniasis is characterized by fever, cachexia, hepatosplenomegaly, pancytopenia, and hypergammaglobulinemia. Cough may be a presenting symptom as well. However, pulmonary involvement is considered rare and mainly described in immunocompromised patients. We describe a case of an immunocompetent adult whose clinical presentation was dominated by cough and hemoptysis. Bronchoscopy revealed a discreet polypoid mucosal endobronchial lesion whose biopsy yielded Leishmania amastigotes within histiocytes. Transbronchial needle biopsy of a right paratracheal lymph node was also positive. Leishmania amastigotes were also found on bone marrow and liver biopsies. Treatment with IV Amphotericin B was successful. In conclusion, cough should not be overlooked as a presenting symptom of visceral leishmaniasis and may be a sign of pulmonary involvement.
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spelling pubmed-30906342011-05-16 Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult Kotsifas, Konstantinos Metaxas, Eugenios Koutsouvelis, Ioannis Skoutelis, Athanassios Kara, Panayiota Tatsis, George Case Rep Med Case Report Visceral leishmaniasis is characterized by fever, cachexia, hepatosplenomegaly, pancytopenia, and hypergammaglobulinemia. Cough may be a presenting symptom as well. However, pulmonary involvement is considered rare and mainly described in immunocompromised patients. We describe a case of an immunocompetent adult whose clinical presentation was dominated by cough and hemoptysis. Bronchoscopy revealed a discreet polypoid mucosal endobronchial lesion whose biopsy yielded Leishmania amastigotes within histiocytes. Transbronchial needle biopsy of a right paratracheal lymph node was also positive. Leishmania amastigotes were also found on bone marrow and liver biopsies. Treatment with IV Amphotericin B was successful. In conclusion, cough should not be overlooked as a presenting symptom of visceral leishmaniasis and may be a sign of pulmonary involvement. Hindawi Publishing Corporation 2011 2011-03-10 /pmc/articles/PMC3090634/ /pubmed/21577261 http://dx.doi.org/10.1155/2011/561985 Text en Copyright © 2011 Konstantinos Kotsifas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kotsifas, Konstantinos
Metaxas, Eugenios
Koutsouvelis, Ioannis
Skoutelis, Athanassios
Kara, Panayiota
Tatsis, George
Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title_full Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title_fullStr Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title_full_unstemmed Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title_short Visceral Leishmaniasis with Endobronchial Involvement in an Immunocompetent Adult
title_sort visceral leishmaniasis with endobronchial involvement in an immunocompetent adult
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090634/
https://www.ncbi.nlm.nih.gov/pubmed/21577261
http://dx.doi.org/10.1155/2011/561985
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