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Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells

BACKGROUND: The survival of glioma patients with the current treatments is poor. Early clinical trails with replicating adenoviruses demonstrated the feasibility and safety of the use of adenoviruses as oncolytic agents. Antitumor efficacy has been moderate due to inefficient virus replication and s...

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Detalles Bibliográficos
Autores principales:	van den Hengel, Sanne K, de Vrij, Jeroen, Uil, Taco G, Lamfers, Martine L, Sillevis Smitt, Peter AE, Hoeben, Rob C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090740/ https://www.ncbi.nlm.nih.gov/pubmed/21477385 http://dx.doi.org/10.1186/1743-422X-8-162

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