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Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study (GWAS) of late-onset Alzheimer disease (LOAD) using a 3 stage design consisting of a discovery stage (Stage 1) and two replication stages (Stages 2 and 3). Both joint and meta-analysis analysis approaches were...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745/ https://www.ncbi.nlm.nih.gov/pubmed/21460841 http://dx.doi.org/10.1038/ng.801 |
| _version_ | 1782203172388864000 |
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| author | Naj, Adam C Jun, Gyungah Beecham, Gary W Wang, Li-San Vardarajan, Badri Narayan Buros, Jacqueline Gallins, Paul J Buxbaum, Joseph D Jarvik, Gail P Crane, Paul K Larson, Eric B Bird, Thomas D Boeve, Bradley F Graff-Radford, Neill R De Jager, Philip L Evans, Denis Schneider, Julie A Carrasquillo, Minerva M Ertekin-Taner, Nilufer Younkin, Steven G Cruchaga, Carlos Kauwe, John SK Nowotny, Petra Kramer, Patricia Hardy, John Huentelman, Matthew J Myers, Amanda J Barmada, Michael M Demirci, F. Yesim Baldwin, Clinton T Green, Robert C Rogaeva, Ekaterina St George-Hyslop, Peter Arnold, Steven E Barber, Robert Beach, Thomas Bigio, Eileen H Bowen, James D Boxer, Adam Burke, James R Cairns, Nigel J Carlson, Chris S Carney, Regina M Carroll, Steven L Chui, Helena C Clark, David G Corneveaux, Jason Cotman, Carl W Cummings, Jeffrey L DeCarli, Charles DeKosky, Steven T Diaz-Arrastia, Ramon Dick, Malcolm Dickson, Dennis W Ellis, William G Faber, Kelley M Fallon, Kenneth B Farlow, Martin R Ferris, Steven Frosch, Matthew P Galasko, Douglas R Ganguli, Mary Gearing, Marla Geschwind, Daniel H Ghetti, Bernardino Gilbert, John R Gilman, Sid Giordani, Bruno Glass, Jonathan D Growdon, John H Hamilton, Ronald L Harrell, Lindy E Head, Elizabeth Honig, Lawrence S Hulette, Christine M Hyman, Bradley T Jicha, Gregory A Jin, Lee-Way Johnson, Nancy Karlawish, Jason Karydas, Anna Kaye, Jeffrey A Kim, Ronald Koo, Edward H Kowall, Neil W Lah, James J Levey, Allan I Lieberman, Andrew P Lopez, Oscar L Mack, Wendy J Marson, Daniel C Martiniuk, Frank Mash, Deborah C Masliah, Eliezer McCormick, Wayne C McCurry, Susan M McDavid, Andrew N McKee, Ann C Mesulam, Marsel Miller, Bruce L Miller, Carol A Miller, Joshua W Parisi, Joseph E Perl, Daniel P Peskind, Elaine Petersen, Ronald C Poon, Wayne W Quinn, Joseph F Rajbhandary, Ruchita A Raskind, Murray Reisberg, Barry Ringman, John M Roberson, Erik D Rosenberg, Roger N Sano, Mary Schneider, Lon S Seeley, William Shelanski, Michael L Slifer, Michael A Smith, Charles D Sonnen, Joshua A Spina, Salvatore Stern, Robert A Tanzi, Rudolph E Trojanowski, John Q Troncoso, Juan C Deerlin, Vivianna M Van Vinters, Harry V Vonsattel, Jean Paul Weintraub, Sandra Welsh-Bohmer, Kathleen A Williamson, Jennifer Woltjer, Randall L Cantwell, Laura B Dombroski, Beth A Beekly, Duane Lunetta, Kathryn L Martin, Eden R Kamboh, M. Ilyas Saykin, Andrew J Reiman, Eric M Bennett, David A Morris, John C Montine, Thomas J Goate, Alison M Blacker, Deborah Tsuang, Debby W Hakonarson, Hakon Kukull, Walter A Foroud, Tatiana M Haines, Jonathan L Mayeux, Richard Pericak-Vance, Margaret A Farrer, Lindsay A Schellenberg, Gerard D |
| author_facet | Naj, Adam C Jun, Gyungah Beecham, Gary W Wang, Li-San Vardarajan, Badri Narayan Buros, Jacqueline Gallins, Paul J Buxbaum, Joseph D Jarvik, Gail P Crane, Paul K Larson, Eric B Bird, Thomas D Boeve, Bradley F Graff-Radford, Neill R De Jager, Philip L Evans, Denis Schneider, Julie A Carrasquillo, Minerva M Ertekin-Taner, Nilufer Younkin, Steven G Cruchaga, Carlos Kauwe, John SK Nowotny, Petra Kramer, Patricia Hardy, John Huentelman, Matthew J Myers, Amanda J Barmada, Michael M Demirci, F. Yesim Baldwin, Clinton T Green, Robert C Rogaeva, Ekaterina St George-Hyslop, Peter Arnold, Steven E Barber, Robert Beach, Thomas Bigio, Eileen H Bowen, James D Boxer, Adam Burke, James R Cairns, Nigel J Carlson, Chris S Carney, Regina M Carroll, Steven L Chui, Helena C Clark, David G Corneveaux, Jason Cotman, Carl W Cummings, Jeffrey L DeCarli, Charles DeKosky, Steven T Diaz-Arrastia, Ramon Dick, Malcolm Dickson, Dennis W Ellis, William G Faber, Kelley M Fallon, Kenneth B Farlow, Martin R Ferris, Steven Frosch, Matthew P Galasko, Douglas R Ganguli, Mary Gearing, Marla Geschwind, Daniel H Ghetti, Bernardino Gilbert, John R Gilman, Sid Giordani, Bruno Glass, Jonathan D Growdon, John H Hamilton, Ronald L Harrell, Lindy E Head, Elizabeth Honig, Lawrence S Hulette, Christine M Hyman, Bradley T Jicha, Gregory A Jin, Lee-Way Johnson, Nancy Karlawish, Jason Karydas, Anna Kaye, Jeffrey A Kim, Ronald Koo, Edward H Kowall, Neil W Lah, James J Levey, Allan I Lieberman, Andrew P Lopez, Oscar L Mack, Wendy J Marson, Daniel C Martiniuk, Frank Mash, Deborah C Masliah, Eliezer McCormick, Wayne C McCurry, Susan M McDavid, Andrew N McKee, Ann C Mesulam, Marsel Miller, Bruce L Miller, Carol A Miller, Joshua W Parisi, Joseph E Perl, Daniel P Peskind, Elaine Petersen, Ronald C Poon, Wayne W Quinn, Joseph F Rajbhandary, Ruchita A Raskind, Murray Reisberg, Barry Ringman, John M Roberson, Erik D Rosenberg, Roger N Sano, Mary Schneider, Lon S Seeley, William Shelanski, Michael L Slifer, Michael A Smith, Charles D Sonnen, Joshua A Spina, Salvatore Stern, Robert A Tanzi, Rudolph E Trojanowski, John Q Troncoso, Juan C Deerlin, Vivianna M Van Vinters, Harry V Vonsattel, Jean Paul Weintraub, Sandra Welsh-Bohmer, Kathleen A Williamson, Jennifer Woltjer, Randall L Cantwell, Laura B Dombroski, Beth A Beekly, Duane Lunetta, Kathryn L Martin, Eden R Kamboh, M. Ilyas Saykin, Andrew J Reiman, Eric M Bennett, David A Morris, John C Montine, Thomas J Goate, Alison M Blacker, Deborah Tsuang, Debby W Hakonarson, Hakon Kukull, Walter A Foroud, Tatiana M Haines, Jonathan L Mayeux, Richard Pericak-Vance, Margaret A Farrer, Lindsay A Schellenberg, Gerard D |
| author_sort | Naj, Adam C |
| collection | PubMed |
| description | The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study (GWAS) of late-onset Alzheimer disease (LOAD) using a 3 stage design consisting of a discovery stage (Stage 1) and two replication stages (Stages 2 and 3). Both joint and meta-analysis analysis approaches were used. We obtained genome-wide significant results at MS4A4A [rs4938933; Stages 1+2, meta-analysis (P(M)) = 1.7 × 10(−9), joint analysis (P(J)) = 1.7 × 10(−9;) Stages 1–3, P(M) = 8.2 × 10(−12)], CD2AP (rs9349407; Stages 1–3, P(M) = 8.6 × 10(−9)), EPHA1 (rs11767557; Stages 1–3 P(M) = 6.0 × 10(−10)), and CD33 (rs3865444; Stages 1–3, P(M) = 1.6 × 10(−9)). We confirmed that CR1 (rs6701713; P(M) = 4.6×10(−10), P(J) = 5.2×10(−11)), CLU (rs1532278; P(M) = 8.3 × 10(−8), P(J) = 1.9×10(−8)), BIN1 (rs7561528; P(M) = 4.0×10(−14); P(J) = 5.2×10(−14)), and PICALM (rs561655; P(M) = 7.0 × 10(−11), P(J) = 1.0×10(−10)) but not EXOC3L2 are LOAD risk loci(1–3). |
| format | Text |
| id | pubmed-3090745 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30907452011-11-01 Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease Naj, Adam C Jun, Gyungah Beecham, Gary W Wang, Li-San Vardarajan, Badri Narayan Buros, Jacqueline Gallins, Paul J Buxbaum, Joseph D Jarvik, Gail P Crane, Paul K Larson, Eric B Bird, Thomas D Boeve, Bradley F Graff-Radford, Neill R De Jager, Philip L Evans, Denis Schneider, Julie A Carrasquillo, Minerva M Ertekin-Taner, Nilufer Younkin, Steven G Cruchaga, Carlos Kauwe, John SK Nowotny, Petra Kramer, Patricia Hardy, John Huentelman, Matthew J Myers, Amanda J Barmada, Michael M Demirci, F. Yesim Baldwin, Clinton T Green, Robert C Rogaeva, Ekaterina St George-Hyslop, Peter Arnold, Steven E Barber, Robert Beach, Thomas Bigio, Eileen H Bowen, James D Boxer, Adam Burke, James R Cairns, Nigel J Carlson, Chris S Carney, Regina M Carroll, Steven L Chui, Helena C Clark, David G Corneveaux, Jason Cotman, Carl W Cummings, Jeffrey L DeCarli, Charles DeKosky, Steven T Diaz-Arrastia, Ramon Dick, Malcolm Dickson, Dennis W Ellis, William G Faber, Kelley M Fallon, Kenneth B Farlow, Martin R Ferris, Steven Frosch, Matthew P Galasko, Douglas R Ganguli, Mary Gearing, Marla Geschwind, Daniel H Ghetti, Bernardino Gilbert, John R Gilman, Sid Giordani, Bruno Glass, Jonathan D Growdon, John H Hamilton, Ronald L Harrell, Lindy E Head, Elizabeth Honig, Lawrence S Hulette, Christine M Hyman, Bradley T Jicha, Gregory A Jin, Lee-Way Johnson, Nancy Karlawish, Jason Karydas, Anna Kaye, Jeffrey A Kim, Ronald Koo, Edward H Kowall, Neil W Lah, James J Levey, Allan I Lieberman, Andrew P Lopez, Oscar L Mack, Wendy J Marson, Daniel C Martiniuk, Frank Mash, Deborah C Masliah, Eliezer McCormick, Wayne C McCurry, Susan M McDavid, Andrew N McKee, Ann C Mesulam, Marsel Miller, Bruce L Miller, Carol A Miller, Joshua W Parisi, Joseph E Perl, Daniel P Peskind, Elaine Petersen, Ronald C Poon, Wayne W Quinn, Joseph F Rajbhandary, Ruchita A Raskind, Murray Reisberg, Barry Ringman, John M Roberson, Erik D Rosenberg, Roger N Sano, Mary Schneider, Lon S Seeley, William Shelanski, Michael L Slifer, Michael A Smith, Charles D Sonnen, Joshua A Spina, Salvatore Stern, Robert A Tanzi, Rudolph E Trojanowski, John Q Troncoso, Juan C Deerlin, Vivianna M Van Vinters, Harry V Vonsattel, Jean Paul Weintraub, Sandra Welsh-Bohmer, Kathleen A Williamson, Jennifer Woltjer, Randall L Cantwell, Laura B Dombroski, Beth A Beekly, Duane Lunetta, Kathryn L Martin, Eden R Kamboh, M. Ilyas Saykin, Andrew J Reiman, Eric M Bennett, David A Morris, John C Montine, Thomas J Goate, Alison M Blacker, Deborah Tsuang, Debby W Hakonarson, Hakon Kukull, Walter A Foroud, Tatiana M Haines, Jonathan L Mayeux, Richard Pericak-Vance, Margaret A Farrer, Lindsay A Schellenberg, Gerard D Nat Genet Article The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study (GWAS) of late-onset Alzheimer disease (LOAD) using a 3 stage design consisting of a discovery stage (Stage 1) and two replication stages (Stages 2 and 3). Both joint and meta-analysis analysis approaches were used. We obtained genome-wide significant results at MS4A4A [rs4938933; Stages 1+2, meta-analysis (P(M)) = 1.7 × 10(−9), joint analysis (P(J)) = 1.7 × 10(−9;) Stages 1–3, P(M) = 8.2 × 10(−12)], CD2AP (rs9349407; Stages 1–3, P(M) = 8.6 × 10(−9)), EPHA1 (rs11767557; Stages 1–3 P(M) = 6.0 × 10(−10)), and CD33 (rs3865444; Stages 1–3, P(M) = 1.6 × 10(−9)). We confirmed that CR1 (rs6701713; P(M) = 4.6×10(−10), P(J) = 5.2×10(−11)), CLU (rs1532278; P(M) = 8.3 × 10(−8), P(J) = 1.9×10(−8)), BIN1 (rs7561528; P(M) = 4.0×10(−14); P(J) = 5.2×10(−14)), and PICALM (rs561655; P(M) = 7.0 × 10(−11), P(J) = 1.0×10(−10)) but not EXOC3L2 are LOAD risk loci(1–3). 2011-04-03 2011-05 /pmc/articles/PMC3090745/ /pubmed/21460841 http://dx.doi.org/10.1038/ng.801 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Naj, Adam C Jun, Gyungah Beecham, Gary W Wang, Li-San Vardarajan, Badri Narayan Buros, Jacqueline Gallins, Paul J Buxbaum, Joseph D Jarvik, Gail P Crane, Paul K Larson, Eric B Bird, Thomas D Boeve, Bradley F Graff-Radford, Neill R De Jager, Philip L Evans, Denis Schneider, Julie A Carrasquillo, Minerva M Ertekin-Taner, Nilufer Younkin, Steven G Cruchaga, Carlos Kauwe, John SK Nowotny, Petra Kramer, Patricia Hardy, John Huentelman, Matthew J Myers, Amanda J Barmada, Michael M Demirci, F. Yesim Baldwin, Clinton T Green, Robert C Rogaeva, Ekaterina St George-Hyslop, Peter Arnold, Steven E Barber, Robert Beach, Thomas Bigio, Eileen H Bowen, James D Boxer, Adam Burke, James R Cairns, Nigel J Carlson, Chris S Carney, Regina M Carroll, Steven L Chui, Helena C Clark, David G Corneveaux, Jason Cotman, Carl W Cummings, Jeffrey L DeCarli, Charles DeKosky, Steven T Diaz-Arrastia, Ramon Dick, Malcolm Dickson, Dennis W Ellis, William G Faber, Kelley M Fallon, Kenneth B Farlow, Martin R Ferris, Steven Frosch, Matthew P Galasko, Douglas R Ganguli, Mary Gearing, Marla Geschwind, Daniel H Ghetti, Bernardino Gilbert, John R Gilman, Sid Giordani, Bruno Glass, Jonathan D Growdon, John H Hamilton, Ronald L Harrell, Lindy E Head, Elizabeth Honig, Lawrence S Hulette, Christine M Hyman, Bradley T Jicha, Gregory A Jin, Lee-Way Johnson, Nancy Karlawish, Jason Karydas, Anna Kaye, Jeffrey A Kim, Ronald Koo, Edward H Kowall, Neil W Lah, James J Levey, Allan I Lieberman, Andrew P Lopez, Oscar L Mack, Wendy J Marson, Daniel C Martiniuk, Frank Mash, Deborah C Masliah, Eliezer McCormick, Wayne C McCurry, Susan M McDavid, Andrew N McKee, Ann C Mesulam, Marsel Miller, Bruce L Miller, Carol A Miller, Joshua W Parisi, Joseph E Perl, Daniel P Peskind, Elaine Petersen, Ronald C Poon, Wayne W Quinn, Joseph F Rajbhandary, Ruchita A Raskind, Murray Reisberg, Barry Ringman, John M Roberson, Erik D Rosenberg, Roger N Sano, Mary Schneider, Lon S Seeley, William Shelanski, Michael L Slifer, Michael A Smith, Charles D Sonnen, Joshua A Spina, Salvatore Stern, Robert A Tanzi, Rudolph E Trojanowski, John Q Troncoso, Juan C Deerlin, Vivianna M Van Vinters, Harry V Vonsattel, Jean Paul Weintraub, Sandra Welsh-Bohmer, Kathleen A Williamson, Jennifer Woltjer, Randall L Cantwell, Laura B Dombroski, Beth A Beekly, Duane Lunetta, Kathryn L Martin, Eden R Kamboh, M. Ilyas Saykin, Andrew J Reiman, Eric M Bennett, David A Morris, John C Montine, Thomas J Goate, Alison M Blacker, Deborah Tsuang, Debby W Hakonarson, Hakon Kukull, Walter A Foroud, Tatiana M Haines, Jonathan L Mayeux, Richard Pericak-Vance, Margaret A Farrer, Lindsay A Schellenberg, Gerard D Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title | Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title_full | Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title_fullStr | Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title_full_unstemmed | Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title_short | Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease |
| title_sort | common variants in ms4a4/ms4a6e, cd2uap, cd33, and epha1 are associated with late-onset alzheimer’s disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745/ https://www.ncbi.nlm.nih.gov/pubmed/21460841 http://dx.doi.org/10.1038/ng.801 |
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