Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically asso...

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Autores principales: Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Kempf, C. Ruth, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C., Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M., Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091517/
https://www.ncbi.nlm.nih.gov/pubmed/21422497
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author Steelman, Linda S.
Chappell, William H.
Abrams, Stephen L.
Kempf, C. Ruth
Long, Jacquelyn
Laidler, Piotr
Mijatovic, Sanja
Maksimovic-Ivanic, Danijela
Stivala, Franca
Mazzarino, Maria C.
Donia, Marco
Fagone, Paolo
Malaponte, Graziella
Nicoletti, Ferdinando
Libra, Massimo
Milella, Michele
Tafuri, Agostino
Bonati, Antonio
Bäsecke, Jörg
Cocco, Lucio
Evangelisti, Camilla
Martelli, Alberto M.
Montalto, Giuseppe
Cervello, Melchiorre
McCubrey, James A.
author_facet Steelman, Linda S.
Chappell, William H.
Abrams, Stephen L.
Kempf, C. Ruth
Long, Jacquelyn
Laidler, Piotr
Mijatovic, Sanja
Maksimovic-Ivanic, Danijela
Stivala, Franca
Mazzarino, Maria C.
Donia, Marco
Fagone, Paolo
Malaponte, Graziella
Nicoletti, Ferdinando
Libra, Massimo
Milella, Michele
Tafuri, Agostino
Bonati, Antonio
Bäsecke, Jörg
Cocco, Lucio
Evangelisti, Camilla
Martelli, Alberto M.
Montalto, Giuseppe
Cervello, Melchiorre
McCubrey, James A.
author_sort Steelman, Linda S.
collection PubMed
description Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.
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spelling pubmed-30915172011-05-12 Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging Steelman, Linda S. Chappell, William H. Abrams, Stephen L. Kempf, C. Ruth Long, Jacquelyn Laidler, Piotr Mijatovic, Sanja Maksimovic-Ivanic, Danijela Stivala, Franca Mazzarino, Maria C. Donia, Marco Fagone, Paolo Malaponte, Graziella Nicoletti, Ferdinando Libra, Massimo Milella, Michele Tafuri, Agostino Bonati, Antonio Bäsecke, Jörg Cocco, Lucio Evangelisti, Camilla Martelli, Alberto M. Montalto, Giuseppe Cervello, Melchiorre McCubrey, James A. Aging (Albany NY) Review Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health. Impact Journals LLC 2011-03-10 /pmc/articles/PMC3091517/ /pubmed/21422497 Text en Copyright: © 2011 Steelman et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Steelman, Linda S.
Chappell, William H.
Abrams, Stephen L.
Kempf, C. Ruth
Long, Jacquelyn
Laidler, Piotr
Mijatovic, Sanja
Maksimovic-Ivanic, Danijela
Stivala, Franca
Mazzarino, Maria C.
Donia, Marco
Fagone, Paolo
Malaponte, Graziella
Nicoletti, Ferdinando
Libra, Massimo
Milella, Michele
Tafuri, Agostino
Bonati, Antonio
Bäsecke, Jörg
Cocco, Lucio
Evangelisti, Camilla
Martelli, Alberto M.
Montalto, Giuseppe
Cervello, Melchiorre
McCubrey, James A.
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title_full Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title_fullStr Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title_full_unstemmed Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title_short Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
title_sort roles of the raf/mek/erk and pi3k/pten/akt/mtor pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091517/
https://www.ncbi.nlm.nih.gov/pubmed/21422497
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