The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibi...

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Detalles Bibliográficos
Autores principales: Ha, Cheol Woong, Huh, Won-Ki
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091525/
https://www.ncbi.nlm.nih.gov/pubmed/21415463
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author Ha, Cheol Woong
Huh, Won-Ki
author_facet Ha, Cheol Woong
Huh, Won-Ki
author_sort Ha, Cheol Woong
collection PubMed
description The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.
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spelling pubmed-30915252011-05-12 The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae Ha, Cheol Woong Huh, Won-Ki Aging (Albany NY) Research Perspective The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways. Impact Journals LLC 2011-03-13 /pmc/articles/PMC3091525/ /pubmed/21415463 Text en Copyright: © 2011 Ha and Huh http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Ha, Cheol Woong
Huh, Won-Ki
The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title_full The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title_fullStr The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title_full_unstemmed The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title_short The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
title_sort implication of sir2 in replicative aging and senescence in saccharomyces cerevisiae
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091525/
https://www.ncbi.nlm.nih.gov/pubmed/21415463
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