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Response of swine spleen to Streptococcus suis infection revealed by transcription analysis
ASTRACT: BACKGROUND: Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases. RESUL...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091705/ https://www.ncbi.nlm.nih.gov/pubmed/20937098 http://dx.doi.org/10.1186/1471-2164-11-556 |
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author | Li, Ran Zhang, Anding Chen, Bo Teng, Liu Wang, Ya Chen, Huanchun Jin, Meilin |
author_facet | Li, Ran Zhang, Anding Chen, Bo Teng, Liu Wang, Ya Chen, Huanchun Jin, Meilin |
author_sort | Li, Ran |
collection | PubMed |
description | ASTRACT: BACKGROUND: Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases. RESULTS: 104 and 129 unique genes were significantly up-regulated and down-regulated in the spleens of pigs infected with SS2 (WT). The up-regulated genes were principally related to immune response, such as genes involved in inflammatory response; acute-phase/immune response; cell adhesion and response to stress. The down-regulated genes were mainly involved in transcription, transport, material and energy metabolism which were representative of the reduced vital activity of SS2-influenced cells. Only a few genes showed significantly differential expression when comparing avirulent isogenic strain (ΔHP0197) with mock-infected samples. CONCLUSIONS: Our findings indicated that highly pathogenic SS2 could persistently induce cytokines mainly by Toll-like receptor 2 (TLR2) pathway, and the phagocytosis-resistant bacteria could induce high level of cytokines and secrete toxins to destroy deep tissues, and cause meningitis, septicaemia, pneumonia, endocarditis, and arthritis. |
format | Text |
id | pubmed-3091705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30917052011-05-11 Response of swine spleen to Streptococcus suis infection revealed by transcription analysis Li, Ran Zhang, Anding Chen, Bo Teng, Liu Wang, Ya Chen, Huanchun Jin, Meilin BMC Genomics Research Article ASTRACT: BACKGROUND: Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases. RESULTS: 104 and 129 unique genes were significantly up-regulated and down-regulated in the spleens of pigs infected with SS2 (WT). The up-regulated genes were principally related to immune response, such as genes involved in inflammatory response; acute-phase/immune response; cell adhesion and response to stress. The down-regulated genes were mainly involved in transcription, transport, material and energy metabolism which were representative of the reduced vital activity of SS2-influenced cells. Only a few genes showed significantly differential expression when comparing avirulent isogenic strain (ΔHP0197) with mock-infected samples. CONCLUSIONS: Our findings indicated that highly pathogenic SS2 could persistently induce cytokines mainly by Toll-like receptor 2 (TLR2) pathway, and the phagocytosis-resistant bacteria could induce high level of cytokines and secrete toxins to destroy deep tissues, and cause meningitis, septicaemia, pneumonia, endocarditis, and arthritis. BioMed Central 2010-10-11 /pmc/articles/PMC3091705/ /pubmed/20937098 http://dx.doi.org/10.1186/1471-2164-11-556 Text en Copyright ©2010 Li et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Ran Zhang, Anding Chen, Bo Teng, Liu Wang, Ya Chen, Huanchun Jin, Meilin Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title | Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title_full | Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title_fullStr | Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title_full_unstemmed | Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title_short | Response of swine spleen to Streptococcus suis infection revealed by transcription analysis |
title_sort | response of swine spleen to streptococcus suis infection revealed by transcription analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091705/ https://www.ncbi.nlm.nih.gov/pubmed/20937098 http://dx.doi.org/10.1186/1471-2164-11-556 |
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