Cargando…

A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks

BACKGROUND: Complex biological processes such as acute inflammation induced by trauma/hemorrhagic shock/ (T/HS) are dynamic and multi-dimensional. We utilized multiplexing cytokine analysis coupled with data-driven modeling to gain a systems perspective into T/HS. METHODOLOGY/PRINCIPAL FINDINGS: Mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mi, Qi, Constantine, Gregory, Ziraldo, Cordelia, Solovyev, Alexey, Torres, Andres, Namas, Rajaie, Bentley, Timothy, Billiar, Timothy R., Zamora, Ruben, Puyana, Juan Carlos, Vodovotz, Yoram
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091861/ https://www.ncbi.nlm.nih.gov/pubmed/21573002 http://dx.doi.org/10.1371/journal.pone.0019424

Ejemplares similares

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
por: Ziraldo, Cordelia, et al.
Publicado: (2013)

An Adequately Robust Early TNF-α Response Is a Hallmark of Survival Following Trauma/Hemorrhage
por: Namas, Rajaie, et al.
Publicado: (2009)

The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
por: Namas, R, et al.
Publicado: (2009)

Time for trauma immunology
por: Billiar, Timothy R., et al.
Publicado: (2017)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice
por: Namas, Rami A., et al.
Publicado: (2013)

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes
por: Schimunek, Lukas, et al.
Publicado: (2019)

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
por: Zaaqoq, Akram M., et al.
Publicado: (2019)

Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling
por: Shah, Ashti M., et al.
Publicado: (2022)

Protective/reparative cytokines are suppressed at high injury severity in human trauma
por: Cai, Jinman, et al.
Publicado: (2021)

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes
por: Schimunek, Lukas, et al.
Publicado: (2021)

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients
por: Liu, Dongmei, et al.
Publicado: (2020)

LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS
por: Chen, Tianmeng, et al.
Publicado: (2022)

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness
por: Chen, Tianmeng, et al.
Publicado: (2022)

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model
por: Xu, Jing, et al.
Publicado: (2017)

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
por: Bonaroti, Jillian, et al.
Publicado: (2022)

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury
por: Ziraldo, Cordelia, et al.
Publicado: (2015)

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice
por: Zettel, Kent, et al.
Publicado: (2017)

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks
por: Zamora, Ruben, et al.
Publicado: (2021)

“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress
por: Vodovotz, Yoram, et al.
Publicado: (2017)

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen
por: Zamora, Ruben, et al.
Publicado: (2019)

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients
por: Abdul-Malak, Othman, et al.
Publicado: (2016)

Analysis of Serum Inflammatory Mediators Identifies Unique Dynamic Networks Associated with Death and Spontaneous Survival in Pediatric Acute Liver Failure
por: Azhar, Nabil, et al.
Publicado: (2013)

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
por: Almahmoud, Khalid, et al.
Publicado: (2019)

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury
por: Savage, Stephanie A., et al.
Publicado: (2020)

A putative “chemokine switch” that regulates systemic acute inflammation in humans
por: Azhar, Nabil, et al.
Publicado: (2021)

A road map from single-cell transcriptome to patient classification for the immune response to trauma
por: Chen, Tianmeng, et al.
Publicado: (2021)

Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis
por: Bagci, Elife Z., et al.
Publicado: (2008)

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice
por: Zamora, Ruben, et al.
Publicado: (2018)

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes
por: El-Dehaibi, Fayten, et al.
Publicado: (2023)

Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock
por: Manson, Joanna, et al.
Publicado: (2019)

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients
por: Constantine, Gregory, et al.
Publicado: (2016)

Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties
por: Zamora, Ruben, et al.
Publicado: (2023)

Molecular mechanisms in the early phase of hemorrhagic shock
por: Hierholzer, Christian, et al.
Publicado: (2001)

Hybrid Equation/Agent-Based Model of Ischemia-Induced Hyperemia and Pressure Ulcer Formation Predicts Greater Propensity to Ulcerate in Subjects with Spinal Cord Injury
por: Solovyev, Alexey, et al.
Publicado: (2013)

A Challenging Twist in Pulmonary Renal Syndrome
por: Namas, Rajaie, et al.
Publicado: (2014)

Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure
por: Vodovotz, Yoram, et al.
Publicado: (2021)

Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus
por: Khan, Reshma M., et al.
Publicado: (2015)

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks
por: Sadowsky, David, et al.
Publicado: (2016)

Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients
por: Abdelhamid, Sultan S., et al.
Publicado: (2022)

Inflammatory signals and network connections implicate cell-mediated immunity in chronic venous insufficiency
por: Vodovotz, Lena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pj2db1mlmbu76a32tljth1g16e