The clinical utility of testicular cancer risk loci

Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any...

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Detalles Bibliográficos
Autores principales: Kratz, Christian P, Bratslavsky, Gennady, Shi, Jianxin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092086/
https://www.ncbi.nlm.nih.gov/pubmed/21255381
http://dx.doi.org/10.1186/gm215
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author Kratz, Christian P
Bratslavsky, Gennady
Shi, Jianxin
author_facet Kratz, Christian P
Bratslavsky, Gennady
Shi, Jianxin
author_sort Kratz, Christian P
collection PubMed
description Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care.
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spelling pubmed-30920862012-01-21 The clinical utility of testicular cancer risk loci Kratz, Christian P Bratslavsky, Gennady Shi, Jianxin Genome Med Commentary Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. BioMed Central 2011-01-21 /pmc/articles/PMC3092086/ /pubmed/21255381 http://dx.doi.org/10.1186/gm215 Text en Copyright ©2011 BioMed Central Ltd.
spellingShingle Commentary
Kratz, Christian P
Bratslavsky, Gennady
Shi, Jianxin
The clinical utility of testicular cancer risk loci
title The clinical utility of testicular cancer risk loci
title_full The clinical utility of testicular cancer risk loci
title_fullStr The clinical utility of testicular cancer risk loci
title_full_unstemmed The clinical utility of testicular cancer risk loci
title_short The clinical utility of testicular cancer risk loci
title_sort clinical utility of testicular cancer risk loci
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092086/
https://www.ncbi.nlm.nih.gov/pubmed/21255381
http://dx.doi.org/10.1186/gm215
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