Defying birth defects through diet?

The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated with a deficiency of transcription factor Cited2 as well as induce cleft palate. These effect...

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Detalles Bibliográficos
Autores principales: Crider, Krista S, Bailey, Lynn B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092094/
https://www.ncbi.nlm.nih.gov/pubmed/21345254
http://dx.doi.org/10.1186/gm223
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author Crider, Krista S
Bailey, Lynn B
author_facet Crider, Krista S
Bailey, Lynn B
author_sort Crider, Krista S
collection PubMed
description The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated with a deficiency of transcription factor Cited2 as well as induce cleft palate. These effects were associated with a more than twofold reduction in embryonic expression of Pitx2c. This investigation suggests the need to further explore this provocative gene-diet interaction in human studies.
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spelling pubmed-30920942012-02-09 Defying birth defects through diet? Crider, Krista S Bailey, Lynn B Genome Med Commentary The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated with a deficiency of transcription factor Cited2 as well as induce cleft palate. These effects were associated with a more than twofold reduction in embryonic expression of Pitx2c. This investigation suggests the need to further explore this provocative gene-diet interaction in human studies. BioMed Central 2011-02-09 /pmc/articles/PMC3092094/ /pubmed/21345254 http://dx.doi.org/10.1186/gm223 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Commentary
Crider, Krista S
Bailey, Lynn B
Defying birth defects through diet?
title Defying birth defects through diet?
title_full Defying birth defects through diet?
title_fullStr Defying birth defects through diet?
title_full_unstemmed Defying birth defects through diet?
title_short Defying birth defects through diet?
title_sort defying birth defects through diet?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092094/
https://www.ncbi.nlm.nih.gov/pubmed/21345254
http://dx.doi.org/10.1186/gm223
work_keys_str_mv AT criderkristas defyingbirthdefectsthroughdiet
AT baileylynnb defyingbirthdefectsthroughdiet

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