Towards an understanding of genetic predisposition to migraine

Plausible genome-wide associations for episodic neurological diseases (such as migraine, epilepsy and ataxias) have been slow to emerge. The first such association was reported in a recent genome-wide association study of migraine, with quantitative expression analysis linking the variant to a nearb...

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Detalles Bibliográficos
Autores principales: Anttila, Verneri, Wessman, Maija, Kallela, Mikko, Palotie, Aarno
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092102/
https://www.ncbi.nlm.nih.gov/pubmed/21457514
http://dx.doi.org/10.1186/gm231
Descripción
Sumario:Plausible genome-wide associations for episodic neurological diseases (such as migraine, epilepsy and ataxias) have been slow to emerge. The first such association was reported in a recent genome-wide association study of migraine, with quantitative expression analysis linking the variant to a nearby regulatory gene, MTDH/AEG-1. This putative mechanism, regulating the expression of the primary glutamate transporter in the brain, EAAT2/GLT-1, has interesting implications bridging the gap between Mendelian and common forms in this key group of disorders.

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