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Inherited destiny? Genetics and gestational diabetes mellitus

Despite years of investigation, very little is known about the genetic predisposition for gestational diabetes mellitus (GDM). However, the advent of genome-wide association and identification of loci contributing to susceptibility to type 2 diabetes mellitus has opened a small window into the genet...

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Detalles Bibliográficos
Autor principal: Watanabe, Richard M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092103/
https://www.ncbi.nlm.nih.gov/pubmed/21457499
http://dx.doi.org/10.1186/gm232
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author Watanabe, Richard M
author_facet Watanabe, Richard M
author_sort Watanabe, Richard M
collection PubMed
description Despite years of investigation, very little is known about the genetic predisposition for gestational diabetes mellitus (GDM). However, the advent of genome-wide association and identification of loci contributing to susceptibility to type 2 diabetes mellitus has opened a small window into the genetics of GDM. More importantly, the study of the genetics of GDM has not only illuminated potential new biology underlying diabetes in pregnancy, but has also provided insights into fetal outcomes. Here, I review some of the insights into GDM and fetal outcomes gained through the study of both rare and common genetic variation. I also discuss whether recent testing of type 2 diabetes mellitus susceptibility loci in GDM case-control samples changes views of whether GDM is a distinct form of diabetes. Finally, I examine how the study of susceptibility loci can be used to influence clinical care, one of the great promises of the new era of human genome analysis.
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spelling pubmed-30921032012-03-25 Inherited destiny? Genetics and gestational diabetes mellitus Watanabe, Richard M Genome Med Review Despite years of investigation, very little is known about the genetic predisposition for gestational diabetes mellitus (GDM). However, the advent of genome-wide association and identification of loci contributing to susceptibility to type 2 diabetes mellitus has opened a small window into the genetics of GDM. More importantly, the study of the genetics of GDM has not only illuminated potential new biology underlying diabetes in pregnancy, but has also provided insights into fetal outcomes. Here, I review some of the insights into GDM and fetal outcomes gained through the study of both rare and common genetic variation. I also discuss whether recent testing of type 2 diabetes mellitus susceptibility loci in GDM case-control samples changes views of whether GDM is a distinct form of diabetes. Finally, I examine how the study of susceptibility loci can be used to influence clinical care, one of the great promises of the new era of human genome analysis. BioMed Central 2011-03-25 /pmc/articles/PMC3092103/ /pubmed/21457499 http://dx.doi.org/10.1186/gm232 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Watanabe, Richard M
Inherited destiny? Genetics and gestational diabetes mellitus
title Inherited destiny? Genetics and gestational diabetes mellitus
title_full Inherited destiny? Genetics and gestational diabetes mellitus
title_fullStr Inherited destiny? Genetics and gestational diabetes mellitus
title_full_unstemmed Inherited destiny? Genetics and gestational diabetes mellitus
title_short Inherited destiny? Genetics and gestational diabetes mellitus
title_sort inherited destiny? genetics and gestational diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092103/
https://www.ncbi.nlm.nih.gov/pubmed/21457499
http://dx.doi.org/10.1186/gm232
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