Insights into cancer mechanisms from genomic research on urological cancers

Molecular mechanisms driving cancer development and progression are rarely unique to one cancer type. Rather, recent genomic studies of urological cancers suggest that common mechanisms recur with variations. Examples include alterations in hypoxia response regulation, epigenetic regulator proteins,...

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Detalles Bibliográficos
Autores principales: Schulz, Wolfgang A, Ribarska, Teodora
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092105/
https://www.ncbi.nlm.nih.gov/pubmed/21457491
http://dx.doi.org/10.1186/gm234
Descripción
Sumario:Molecular mechanisms driving cancer development and progression are rarely unique to one cancer type. Rather, recent genomic studies of urological cancers suggest that common mechanisms recur with variations. Examples include alterations in hypoxia response regulation, epigenetic regulator proteins, and signal transduction pathways in renal, prostatic and urothelial carcinomas. Consideration of these variations alongside the common basic cancer mechanisms might be important for the successful development of targeted therapies.

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