p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

p53 suppresses tumor progression and metastasis. Epithelial–mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 and ZEB2 promote EMT. Here, we show that p53 suppresses EMT by repressing expression of ZEB1 and ZEB2. By profiling 92 primary...

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Detalles Bibliográficos
Autores principales: Kim, Taewan, Veronese, Angelo, Pichiorri, Flavia, Lee, Tae Jin, Jeon, Young-Jun, Volinia, Stefano, Pineau, Pascal, Marchio, Agnès, Palatini, Jeff, Suh, Sung-Suk, Alder, Hansjuerg, Liu, Chang–Gong, Dejean, Anne, Croce, Carlo M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092351/
https://www.ncbi.nlm.nih.gov/pubmed/21518799
http://dx.doi.org/10.1084/jem.20110235

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