Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

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Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function mutations in IL7R in pediatric B and T acute lymphoblastic leukemias. The mutat...

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Detalles Bibliográficos
Autores principales: Shochat, Chen, Tal, Noa, Bandapalli, Obul R., Palmi, Chiara, Ganmore, Ithamar, te Kronnie, Geertruy, Cario, Gunnar, Cazzaniga, Giovanni, Kulozik, Andreas E., Stanulla, Martin, Schrappe, Martin, Biondi, Andrea, Basso, Giuseppe, Bercovich, Dani, Muckenthaler, Martina U., Izraeli, Shai
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092356/
https://www.ncbi.nlm.nih.gov/pubmed/21536738
http://dx.doi.org/10.1084/jem.20110580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092356/
https://www.ncbi.nlm.nih.gov/pubmed/21536738
http://dx.doi.org/10.1084/jem.20110580

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