Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI

This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhirde, Ashwinkumar, Guo, Ning, Chen, Xiaoyuan
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092450/
https://www.ncbi.nlm.nih.gov/pubmed/21562633
Descripción
Sumario:This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.

Ejemplares similares