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Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expressi...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092450/ https://www.ncbi.nlm.nih.gov/pubmed/21562633 |
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author | Bhirde, Ashwinkumar Guo, Ning Chen, Xiaoyuan |
author_facet | Bhirde, Ashwinkumar Guo, Ning Chen, Xiaoyuan |
author_sort | Bhirde, Ashwinkumar |
collection | PubMed |
description | This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes. |
format | Text |
id | pubmed-3092450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-30924502011-05-11 Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI Bhirde, Ashwinkumar Guo, Ning Chen, Xiaoyuan Theranostics Commentary This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes. Ivyspring International Publisher 2011-04-26 /pmc/articles/PMC3092450/ /pubmed/21562633 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Commentary Bhirde, Ashwinkumar Guo, Ning Chen, Xiaoyuan Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title | Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title_full | Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title_fullStr | Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title_full_unstemmed | Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title_short | Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI |
title_sort | targeted nanoprobes reveal early time point kinetics in vivo by time-resolved mri |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092450/ https://www.ncbi.nlm.nih.gov/pubmed/21562633 |
work_keys_str_mv | AT bhirdeashwinkumar targetednanoprobesrevealearlytimepointkineticsinvivobytimeresolvedmri AT guoning targetednanoprobesrevealearlytimepointkineticsinvivobytimeresolvedmri AT chenxiaoyuan targetednanoprobesrevealearlytimepointkineticsinvivobytimeresolvedmri |