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Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI

This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expressi...

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Detalles Bibliográficos
Autores principales: Bhirde, Ashwinkumar, Guo, Ning, Chen, Xiaoyuan
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092450/
https://www.ncbi.nlm.nih.gov/pubmed/21562633
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author Bhirde, Ashwinkumar
Guo, Ning
Chen, Xiaoyuan
author_facet Bhirde, Ashwinkumar
Guo, Ning
Chen, Xiaoyuan
author_sort Bhirde, Ashwinkumar
collection PubMed
description This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.
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spelling pubmed-30924502011-05-11 Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI Bhirde, Ashwinkumar Guo, Ning Chen, Xiaoyuan Theranostics Commentary This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes. Ivyspring International Publisher 2011-04-26 /pmc/articles/PMC3092450/ /pubmed/21562633 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Commentary
Bhirde, Ashwinkumar
Guo, Ning
Chen, Xiaoyuan
Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title_full Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title_fullStr Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title_full_unstemmed Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title_short Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI
title_sort targeted nanoprobes reveal early time point kinetics in vivo by time-resolved mri
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092450/
https://www.ncbi.nlm.nih.gov/pubmed/21562633
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