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The Role of Manganese Superoxide Dismutase in Skin Cancer

Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can...

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Detalles Bibliográficos
Autores principales: Robbins, Delira, Zhao, Yunfeng
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092576/
https://www.ncbi.nlm.nih.gov/pubmed/21603266
http://dx.doi.org/10.4061/2011/409295
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author Robbins, Delira
Zhao, Yunfeng
author_facet Robbins, Delira
Zhao, Yunfeng
author_sort Robbins, Delira
collection PubMed
description Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can be induced by exogenous sources, resulting in protective effects against associated oxidative injury. Many studies have shown that the induction of antioxidants is an effective strategy to combat various disease states. In one approach, a SOD mimetic was applied topically to mouse skin in the two-stage skin carcinogenesis model. This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumor incidence and multiplicity by 33% and 57%, respectively. These studies suggest that alterations in antioxidant response may be a novel approach to chemoprevention. This paper focuses on how regulation of antioxidant expression and activity can be modulated in skin disease and the potential clinical implications of antioxidant-based therapies.
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spelling pubmed-30925762011-05-20 The Role of Manganese Superoxide Dismutase in Skin Cancer Robbins, Delira Zhao, Yunfeng Enzyme Res Review Article Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can be induced by exogenous sources, resulting in protective effects against associated oxidative injury. Many studies have shown that the induction of antioxidants is an effective strategy to combat various disease states. In one approach, a SOD mimetic was applied topically to mouse skin in the two-stage skin carcinogenesis model. This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumor incidence and multiplicity by 33% and 57%, respectively. These studies suggest that alterations in antioxidant response may be a novel approach to chemoprevention. This paper focuses on how regulation of antioxidant expression and activity can be modulated in skin disease and the potential clinical implications of antioxidant-based therapies. SAGE-Hindawi Access to Research 2011-03-23 /pmc/articles/PMC3092576/ /pubmed/21603266 http://dx.doi.org/10.4061/2011/409295 Text en Copyright © 2011 D. Robbins and Y. Zhao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Robbins, Delira
Zhao, Yunfeng
The Role of Manganese Superoxide Dismutase in Skin Cancer
title The Role of Manganese Superoxide Dismutase in Skin Cancer
title_full The Role of Manganese Superoxide Dismutase in Skin Cancer
title_fullStr The Role of Manganese Superoxide Dismutase in Skin Cancer
title_full_unstemmed The Role of Manganese Superoxide Dismutase in Skin Cancer
title_short The Role of Manganese Superoxide Dismutase in Skin Cancer
title_sort role of manganese superoxide dismutase in skin cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092576/
https://www.ncbi.nlm.nih.gov/pubmed/21603266
http://dx.doi.org/10.4061/2011/409295
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