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Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications

Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in...

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Autores principales: Mathur, Sandeep Kumar, Jain, Priyanka, Mathur, Prashant
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092611/
https://www.ncbi.nlm.nih.gov/pubmed/21603273
http://dx.doi.org/10.1155/2011/587495
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author Mathur, Sandeep Kumar
Jain, Priyanka
Mathur, Prashant
author_facet Mathur, Sandeep Kumar
Jain, Priyanka
Mathur, Prashant
author_sort Mathur, Sandeep Kumar
collection PubMed
description Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome.
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spelling pubmed-30926112011-05-20 Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications Mathur, Sandeep Kumar Jain, Priyanka Mathur, Prashant J Obes Review Article Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome. Hindawi Publishing Corporation 2011 2011-04-28 /pmc/articles/PMC3092611/ /pubmed/21603273 http://dx.doi.org/10.1155/2011/587495 Text en Copyright © 2011 Sandeep Kumar Mathur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mathur, Sandeep Kumar
Jain, Priyanka
Mathur, Prashant
Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title_full Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title_fullStr Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title_full_unstemmed Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title_short Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
title_sort microarray evidences the role of pathologic adipose tissue in insulin resistance and their clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092611/
https://www.ncbi.nlm.nih.gov/pubmed/21603273
http://dx.doi.org/10.1155/2011/587495
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