Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease

Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease....

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Autores principales: Aylward, Elizabeth, Mills, James, Liu, Dawei, Nopoulos, Peggy, Ross, Christopher A., Pierson, Ronald, Paulsen, Jane S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092625/
https://www.ncbi.nlm.nih.gov/pubmed/21593963
http://dx.doi.org/10.1371/currents.RRN1235
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author Aylward, Elizabeth
Mills, James
Liu, Dawei
Nopoulos, Peggy
Ross, Christopher A.
Pierson, Ronald
Paulsen, Jane S.
author_facet Aylward, Elizabeth
Mills, James
Liu, Dawei
Nopoulos, Peggy
Ross, Christopher A.
Pierson, Ronald
Paulsen, Jane S.
author_sort Aylward, Elizabeth
collection PubMed
description Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38–39, 40, 41, 42, 43, 44, 45, 46, and 47–54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.
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spelling pubmed-30926252011-05-17 Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease Aylward, Elizabeth Mills, James Liu, Dawei Nopoulos, Peggy Ross, Christopher A. Pierson, Ronald Paulsen, Jane S. PLoS Curr Huntington Disease Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38–39, 40, 41, 42, 43, 44, 45, 46, and 47–54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths. Public Library of Science 2011-05-11 /pmc/articles/PMC3092625/ /pubmed/21593963 http://dx.doi.org/10.1371/currents.RRN1235 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Huntington Disease
Aylward, Elizabeth
Mills, James
Liu, Dawei
Nopoulos, Peggy
Ross, Christopher A.
Pierson, Ronald
Paulsen, Jane S.
Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title_full Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title_fullStr Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title_full_unstemmed Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title_short Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
title_sort association between age and striatal volume stratified by cag repeat length in prodromal huntington disease
topic Huntington Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092625/
https://www.ncbi.nlm.nih.gov/pubmed/21593963
http://dx.doi.org/10.1371/currents.RRN1235
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