Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals

BACKGROUND: Nevirapine is metabolized by CYP2B6 and polymorphisms within the CYP2B6 gene partly explain inter-patient variability in pharmacokinetics. The aim of this study was to model the complex relationship between nevirapine exposure, weight and genetics (based on combined analysis of CYP2B6 51...

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Detalles Bibliográficos
Autores principales: Schipani, Alessandro, Wyen, Christoph, Mahungu, Tabitha, Hendra, Heidy, Egan, Deirdre, Siccardi, Marco, Davies, Gerry, Khoo, Saye, Fätkenheuer, Gerd, Youle, Michael, Rockstroh, Jürgen, Brockmeyer, Norbert H., Johnson, Margaret A., Owen, Andrew, Back, David J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092713/
https://www.ncbi.nlm.nih.gov/pubmed/21441248
http://dx.doi.org/10.1093/jac/dkr087

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