Nrt1 and Tna1-Independent Export of NAD(+) Precursor Vitamins Promotes NAD(+) Homeostasis and Allows Engineering of Vitamin Production

NAD(+) is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD(+) consuming enzymes. NAD(+) biosynthesis is required for two different regimens that extend lifespan in yeast. NAD(+) is synthesized from tryptophan and the three vitamin precursors of NAD(+): nicotini...

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Detalles Bibliográficos
Autores principales: Belenky, Peter, Stebbins, Rebecca, Bogan, Katrina L., Evans, Charles R., Brenner, Charles
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092764/
https://www.ncbi.nlm.nih.gov/pubmed/21589930
http://dx.doi.org/10.1371/journal.pone.0019710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092764/
https://www.ncbi.nlm.nih.gov/pubmed/21589930
http://dx.doi.org/10.1371/journal.pone.0019710

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