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Nrt1 and Tna1-Independent Export of NAD(+) Precursor Vitamins Promotes NAD(+) Homeostasis and Allows Engineering of Vitamin Production
NAD(+) is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD(+) consuming enzymes. NAD(+) biosynthesis is required for two different regimens that extend lifespan in yeast. NAD(+) is synthesized from tryptophan and the three vitamin precursors of NAD(+): nicotini...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092764/ https://www.ncbi.nlm.nih.gov/pubmed/21589930 http://dx.doi.org/10.1371/journal.pone.0019710 |