Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes

A series of 2-amino-4-aryl-3-cyano-7- (dimethylamino)-4H-chromenes was synthesized by condensation of 3- (dimethylamino) phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass...

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Autores principales: Vosooghi, M., Rajabalian, S., Sorkhi, M., Badinloo, M., Nakhjiri, M., Negahbani, A.S., Asadipour, A., Mahdavi, M., Shafiee, A., Foroumadi, A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093096/
https://www.ncbi.nlm.nih.gov/pubmed/21589763
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author Vosooghi, M.
Rajabalian, S.
Sorkhi, M.
Badinloo, M.
Nakhjiri, M.
Negahbani, A.S.
Asadipour, A.
Mahdavi, M.
Shafiee, A.
Foroumadi, A.
author_facet Vosooghi, M.
Rajabalian, S.
Sorkhi, M.
Badinloo, M.
Nakhjiri, M.
Negahbani, A.S.
Asadipour, A.
Mahdavi, M.
Shafiee, A.
Foroumadi, A.
author_sort Vosooghi, M.
collection PubMed
description A series of 2-amino-4-aryl-3-cyano-7- (dimethylamino)-4H-chromenes was synthesized by condensation of 3- (dimethylamino) phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass and(1)H NMR). The cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by MTT assay. Several compounds showed significant cytotoxic activity.
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spelling pubmed-30930962011-05-17 Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes Vosooghi, M. Rajabalian, S. Sorkhi, M. Badinloo, M. Nakhjiri, M. Negahbani, A.S. Asadipour, A. Mahdavi, M. Shafiee, A. Foroumadi, A. Res Pharm Sci Original Article A series of 2-amino-4-aryl-3-cyano-7- (dimethylamino)-4H-chromenes was synthesized by condensation of 3- (dimethylamino) phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass and(1)H NMR). The cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by MTT assay. Several compounds showed significant cytotoxic activity. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3093096/ /pubmed/21589763 Text en Copyright: © Journal of Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vosooghi, M.
Rajabalian, S.
Sorkhi, M.
Badinloo, M.
Nakhjiri, M.
Negahbani, A.S.
Asadipour, A.
Mahdavi, M.
Shafiee, A.
Foroumadi, A.
Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title_full Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title_fullStr Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title_full_unstemmed Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title_short Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes
title_sort synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4h-chromenes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093096/
https://www.ncbi.nlm.nih.gov/pubmed/21589763
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