Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes

Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fAβ). Here we show that in primary microglia a chloride transporter, ClC-7, is not delivered efficiently to lysosomes, causing incomplete lysosomal acidification. ClC-7...

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Detalles Bibliográficos
Autores principales: Majumdar, Amitabha, Capetillo-Zarate, Estibaliz, Cruz, Dana, Gouras, Gunnar K., Maxfield, Frederick R.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093319/
https://www.ncbi.nlm.nih.gov/pubmed/21441306
http://dx.doi.org/10.1091/mbc.E10-09-0745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093319/
https://www.ncbi.nlm.nih.gov/pubmed/21441306
http://dx.doi.org/10.1091/mbc.E10-09-0745

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