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Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes
Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fAβ). Here we show that in primary microglia a chloride transporter, ClC-7, is not delivered efficiently to lysosomes, causing incomplete lysosomal acidification. ClC-7...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093319/ https://www.ncbi.nlm.nih.gov/pubmed/21441306 http://dx.doi.org/10.1091/mbc.E10-09-0745 |