The Antiviral Efficacy of HIV-Specific CD8(+) T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate

A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef(90–97) epitope FL8 share...

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Detalles Bibliográficos
Autores principales: Ranasinghe, Srinika R. F., Kramer, Holger B., Wright, Cynthia, Kessler, Benedikt M., di Gleria, Katalin, Zhang, Yonghong, Gillespie, Geraldine M., Blais, Marie-Eve, Culshaw, Abigail, Pichulik, Tica, Simmons, Alison, Rowland-Jones, Sarah L., McMichael, Andrew J., Dong, Tao
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093356/
https://www.ncbi.nlm.nih.gov/pubmed/21589893
http://dx.doi.org/10.1371/journal.ppat.1001341

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