Cargando…
Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction
Genome-wide association studies of gene-environment interaction (GxE GWAS) are becoming popular. As with main effects GWAS, quantile-quantile plots (QQ-plots) and Genomic Control are being used to assess and correct for population substructure. However, in G[Image: see text]E work these approaches c...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093379/ https://www.ncbi.nlm.nih.gov/pubmed/21589913 http://dx.doi.org/10.1371/journal.pone.0019416 |
_version_ | 1782203468151259136 |
---|---|
author | Voorman, Arend Lumley, Thomas McKnight, Barbara Rice, Kenneth |
author_facet | Voorman, Arend Lumley, Thomas McKnight, Barbara Rice, Kenneth |
author_sort | Voorman, Arend |
collection | PubMed |
description | Genome-wide association studies of gene-environment interaction (GxE GWAS) are becoming popular. As with main effects GWAS, quantile-quantile plots (QQ-plots) and Genomic Control are being used to assess and correct for population substructure. However, in G[Image: see text]E work these approaches can be seriously misleading, as we illustrate; QQ-plots may give strong indications of substructure when absolutely none is present. Using simulation and theory, we show how and why spurious QQ-plot inflation occurs in G[Image: see text]E GWAS, and how this differs from main-effects analyses. We also explain how simple adjustments to standard regression-based methods used in G[Image: see text]E GWAS can alleviate this problem. |
format | Text |
id | pubmed-3093379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30933792011-05-17 Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction Voorman, Arend Lumley, Thomas McKnight, Barbara Rice, Kenneth PLoS One Research Article Genome-wide association studies of gene-environment interaction (GxE GWAS) are becoming popular. As with main effects GWAS, quantile-quantile plots (QQ-plots) and Genomic Control are being used to assess and correct for population substructure. However, in G[Image: see text]E work these approaches can be seriously misleading, as we illustrate; QQ-plots may give strong indications of substructure when absolutely none is present. Using simulation and theory, we show how and why spurious QQ-plot inflation occurs in G[Image: see text]E GWAS, and how this differs from main-effects analyses. We also explain how simple adjustments to standard regression-based methods used in G[Image: see text]E GWAS can alleviate this problem. Public Library of Science 2011-05-12 /pmc/articles/PMC3093379/ /pubmed/21589913 http://dx.doi.org/10.1371/journal.pone.0019416 Text en Voorman et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Voorman, Arend Lumley, Thomas McKnight, Barbara Rice, Kenneth Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title | Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title_full | Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title_fullStr | Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title_full_unstemmed | Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title_short | Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction |
title_sort | behavior of qq-plots and genomic control in studies of gene-environment interaction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093379/ https://www.ncbi.nlm.nih.gov/pubmed/21589913 http://dx.doi.org/10.1371/journal.pone.0019416 |
work_keys_str_mv | AT voormanarend behaviorofqqplotsandgenomiccontrolinstudiesofgeneenvironmentinteraction AT lumleythomas behaviorofqqplotsandgenomiccontrolinstudiesofgeneenvironmentinteraction AT mcknightbarbara behaviorofqqplotsandgenomiccontrolinstudiesofgeneenvironmentinteraction AT ricekenneth behaviorofqqplotsandgenomiccontrolinstudiesofgeneenvironmentinteraction |