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Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation

BACKGROUND: Adult mesenchymal stem cells (MSCs) can be maintained over extended periods of time before activation and differentiation. Little is known about the programs that sustain the survival of these cells. PRINCIPAL FINDINGS: Undifferentiated adult human MSCs (hMSCs) did not undergo apoptosis...

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Detalles Bibliográficos
Autores principales: Oliver, Lisa, Hue, Erika, Rossignol, Julien, Bougras, Gwenola, Hulin, Philippe, Naveilhan, Philippe, Heymann, Dominique, Lescaudron, Laurent, Vallette, François M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093403/
https://www.ncbi.nlm.nih.gov/pubmed/21589877
http://dx.doi.org/10.1371/journal.pone.0019820