A novel tumor suppressor function for the Notch pathway in myeloid leukemia

Notch signaling is a central regulator of differentiation in a variety of organisms and tissue types(1). Its activity is controlled by the multi-subunit γ–secretase complex (γSE) complex(2). Although Notch signaling can play both oncogenic and tumor suppressor roles in solid tumors, in the hematopoi...

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Detalles Bibliográficos
Autores principales: Klinakis, Apostolos, Lobry, Camille, Abdel-Wahab, Omar, Oh, Philmo, Haeno, Hiroshi, Buonamici, Silvia, van De Walle, Inge, Cathelin, Severine, Trimarchi, Thomas, Araldi, Elisa, Liu, Cynthia, Ibrahim, Sherif, Beran, Miroslav, Zavadil, Jiri, Efstratiadis, Argiris, Taghon, Tom, Michor, Franziska, Levine, Ross L., Aifantis, Iannis
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093658/
https://www.ncbi.nlm.nih.gov/pubmed/21562564
http://dx.doi.org/10.1038/nature09999

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