Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

[Image: see text] N(1)-Hydroxy-N(8)-ferrocenyloctanediamide, JAHA (7), an organometallic analogue of SAHA containing a ferrocenyl group as a phenyl bioisostere, displays nanomolar inhibition of class I HDACs, excellent selectivity over class IIa HDACs, and anticancer action in intact cells (IC(50) =...

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Detalles Bibliográficos
Autores principales: Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S. Syed, Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E., Heightman, Tom D.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093745/
https://www.ncbi.nlm.nih.gov/pubmed/21572592
http://dx.doi.org/10.1021/ml100295v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093745/
https://www.ncbi.nlm.nih.gov/pubmed/21572592
http://dx.doi.org/10.1021/ml100295v

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