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Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction

Tumor necrosis factor alpha (TNFα) and its receptor TNFR1 play a central role in the development of colitis-associated colon cancer. To understand a role for the extracellular calcium-sensing receptor (CaSR) and its non-canonical Wnt mediators, Wnt5a/Ror2, we used reductionistic systems. We added li...

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Detalles Bibliográficos
Autores principales:	Kelly, Jacqueline C., Lungchukiet, P., MacLeod, R. John
Formato:	Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2011
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093814/ https://www.ncbi.nlm.nih.gov/pubmed/21603229 http://dx.doi.org/10.3389/fphys.2011.00017

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