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Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I: A SINGLE, UNIFIED MECHANISM THAT APPLIES DURING BOTH FORWARD AND REVERSE ELECTRON TRANSFER

NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a contributor to cellular oxidative stress. In isolated complex I the reduced flavin is known to react with molecular oxygen to form predominantly superoxide, but studies using intact mitochon...

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Detalles Bibliográficos
Autores principales:	Pryde, Kenneth R., Hirst, Judy
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093879/ https://www.ncbi.nlm.nih.gov/pubmed/21393237 http://dx.doi.org/10.1074/jbc.M110.186841

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