Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys

Objectives. To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion activity with the mutated 2LM20-4 P331S [no in vitro complement-dependent cytotoxicity (CDC)] and rituxima...

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Detalles Bibliográficos
Autores principales: Nickerson-Nutter, Cheryl, Tchistiakova, Lioudmila, Seth, Nilufer P., Kasaian, Marion, Sibley, Barbara, Olland, Stephane, Zollner, Richard, Brady, William A., Mohler, Kendall M., Baum, Peter, Wahl, Alan, Herber, Deborah, Vugmeyster, Yulia, Wensel, David, Wolfman, Neil M., Gill, Davinder, Collins, Mary, Dunussi-Joannopoulos, Kyri
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093928/
https://www.ncbi.nlm.nih.gov/pubmed/21258049
http://dx.doi.org/10.1093/rheumatology/keq423

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