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Liver transplantation in Greek children: 15 years experience

Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients rec...

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Autores principales: Xinias, Ioannis, Mavroudi, Antigoni, Vrani, Olga, Imvrios, Georgios, Takoudas, Dimitrios, Spiroglou, Kleomenis
Formato: Texto
Lenguaje:English
Publicado: PAGEPress Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094000/
https://www.ncbi.nlm.nih.gov/pubmed/21589827
http://dx.doi.org/10.4081/pr.2010.e14
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author Xinias, Ioannis
Mavroudi, Antigoni
Vrani, Olga
Imvrios, Georgios
Takoudas, Dimitrios
Spiroglou, Kleomenis
author_facet Xinias, Ioannis
Mavroudi, Antigoni
Vrani, Olga
Imvrios, Georgios
Takoudas, Dimitrios
Spiroglou, Kleomenis
author_sort Xinias, Ioannis
collection PubMed
description Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation) due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclosporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV(1,2), 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation. The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers.
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spelling pubmed-30940002011-05-17 Liver transplantation in Greek children: 15 years experience Xinias, Ioannis Mavroudi, Antigoni Vrani, Olga Imvrios, Georgios Takoudas, Dimitrios Spiroglou, Kleomenis Pediatr Rep Article Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation) due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclosporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV(1,2), 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation. The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers. PAGEPress Publications 2010-09-06 /pmc/articles/PMC3094000/ /pubmed/21589827 http://dx.doi.org/10.4081/pr.2010.e14 Text en ©Copyright I. Xinias et al. 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
spellingShingle Article
Xinias, Ioannis
Mavroudi, Antigoni
Vrani, Olga
Imvrios, Georgios
Takoudas, Dimitrios
Spiroglou, Kleomenis
Liver transplantation in Greek children: 15 years experience
title Liver transplantation in Greek children: 15 years experience
title_full Liver transplantation in Greek children: 15 years experience
title_fullStr Liver transplantation in Greek children: 15 years experience
title_full_unstemmed Liver transplantation in Greek children: 15 years experience
title_short Liver transplantation in Greek children: 15 years experience
title_sort liver transplantation in greek children: 15 years experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094000/
https://www.ncbi.nlm.nih.gov/pubmed/21589827
http://dx.doi.org/10.4081/pr.2010.e14
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AT imvriosgeorgios livertransplantationingreekchildren15yearsexperience
AT takoudasdimitrios livertransplantationingreekchildren15yearsexperience
AT spirogloukleomenis livertransplantationingreekchildren15yearsexperience