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Liver transplantation in Greek children: 15 years experience
Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients rec...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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PAGEPress Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094000/ https://www.ncbi.nlm.nih.gov/pubmed/21589827 http://dx.doi.org/10.4081/pr.2010.e14 |
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author | Xinias, Ioannis Mavroudi, Antigoni Vrani, Olga Imvrios, Georgios Takoudas, Dimitrios Spiroglou, Kleomenis |
author_facet | Xinias, Ioannis Mavroudi, Antigoni Vrani, Olga Imvrios, Georgios Takoudas, Dimitrios Spiroglou, Kleomenis |
author_sort | Xinias, Ioannis |
collection | PubMed |
description | Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation) due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclosporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV(1,2), 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation. The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers. |
format | Text |
id | pubmed-3094000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30940002011-05-17 Liver transplantation in Greek children: 15 years experience Xinias, Ioannis Mavroudi, Antigoni Vrani, Olga Imvrios, Georgios Takoudas, Dimitrios Spiroglou, Kleomenis Pediatr Rep Article Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation) due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclosporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV(1,2), 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation. The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers. PAGEPress Publications 2010-09-06 /pmc/articles/PMC3094000/ /pubmed/21589827 http://dx.doi.org/10.4081/pr.2010.e14 Text en ©Copyright I. Xinias et al. 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy |
spellingShingle | Article Xinias, Ioannis Mavroudi, Antigoni Vrani, Olga Imvrios, Georgios Takoudas, Dimitrios Spiroglou, Kleomenis Liver transplantation in Greek children: 15 years experience |
title | Liver transplantation in Greek children: 15 years experience |
title_full | Liver transplantation in Greek children: 15 years experience |
title_fullStr | Liver transplantation in Greek children: 15 years experience |
title_full_unstemmed | Liver transplantation in Greek children: 15 years experience |
title_short | Liver transplantation in Greek children: 15 years experience |
title_sort | liver transplantation in greek children: 15 years experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094000/ https://www.ncbi.nlm.nih.gov/pubmed/21589827 http://dx.doi.org/10.4081/pr.2010.e14 |
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