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Placentation in Sigmodontinae: a rodent taxon native to South America

BACKGROUND: Sigmodontinae, known as "New World rats and mice," is a large subfamily of Cricetidae for which we herein provide the first comprehensive investigation of the placenta. METHODS: Placentas of various gestational ages ranging from early pregnancy to near term were obtained for fi...

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Autores principales: Favaron, Phelipe O, Carter, Anthony M, Ambrósio, Carlos E, Morini, Adriana C, Mess, Andrea M, de Oliveira, Moacir F, Miglino, Maria A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094283/
https://www.ncbi.nlm.nih.gov/pubmed/21518439
http://dx.doi.org/10.1186/1477-7827-9-55
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author Favaron, Phelipe O
Carter, Anthony M
Ambrósio, Carlos E
Morini, Adriana C
Mess, Andrea M
de Oliveira, Moacir F
Miglino, Maria A
author_facet Favaron, Phelipe O
Carter, Anthony M
Ambrósio, Carlos E
Morini, Adriana C
Mess, Andrea M
de Oliveira, Moacir F
Miglino, Maria A
author_sort Favaron, Phelipe O
collection PubMed
description BACKGROUND: Sigmodontinae, known as "New World rats and mice," is a large subfamily of Cricetidae for which we herein provide the first comprehensive investigation of the placenta. METHODS: Placentas of various gestational ages ranging from early pregnancy to near term were obtained for five genera, i.e. Necromys, Euryoryzomys, Cerradomys, Hylaeamys, and Oligoryzomys. They were investigated by means of histology, immunohistochemistry, a proliferation marker, DBA-lectin staining and transmission electron microscopy. RESULTS: The chorioallantoic placenta was organized in a labyrinthine zone, spongy zone and decidua and an inverted yolk sac persisted until term. The chorioallantoic placenta was hemotrichorial. The interhemal barrier comprised fetal capillary endothelium and three layers of trophoblast, an outermost, cellular layer and two syncytial ones, with interspersed trophoblast giant cells (TGC). In addition, accumulations of TGC occurred below Reichert's membrane. The junctional zone contained syncytial trophoblast, proliferative cellular trophoblast, glycogen cells and TGC that were situated near to the maternal blood channels. In three of the genera, TGC were also accumulated in distinct areas at the placental periphery. PAS-positive glycogen cells derived from the junctional zone invaded the decidua. Abundant maternal uNK cells with positive response to PAS, vimentin and DBA-lectin were found in the decidua. The visceral yolk sac was completely inverted and villous. CONCLUSION: The general aspect of the fetal membranes in Sigmodontinae resembled that found in other cricetid rodents. Compared to murid rodents there were larger numbers of giant cells and in some genera these were seen to congregate at the periphery of the placental disk. Glycogen cells were found to invade the decidua but we did not identify trophoblast in the walls of the deeper decidual arteries. In contrast these vessels were surrounded by large numbers of uNK cells. This survey of wild-trapped specimens from five genera is a useful starting point for the study of placentation in an important subfamily of South American rodents. We note, however, that some of these rodents can be captive bred and recommend that future studies focus on the study of time dated pregnancies.
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spelling pubmed-30942832011-05-14 Placentation in Sigmodontinae: a rodent taxon native to South America Favaron, Phelipe O Carter, Anthony M Ambrósio, Carlos E Morini, Adriana C Mess, Andrea M de Oliveira, Moacir F Miglino, Maria A Reprod Biol Endocrinol Research BACKGROUND: Sigmodontinae, known as "New World rats and mice," is a large subfamily of Cricetidae for which we herein provide the first comprehensive investigation of the placenta. METHODS: Placentas of various gestational ages ranging from early pregnancy to near term were obtained for five genera, i.e. Necromys, Euryoryzomys, Cerradomys, Hylaeamys, and Oligoryzomys. They were investigated by means of histology, immunohistochemistry, a proliferation marker, DBA-lectin staining and transmission electron microscopy. RESULTS: The chorioallantoic placenta was organized in a labyrinthine zone, spongy zone and decidua and an inverted yolk sac persisted until term. The chorioallantoic placenta was hemotrichorial. The interhemal barrier comprised fetal capillary endothelium and three layers of trophoblast, an outermost, cellular layer and two syncytial ones, with interspersed trophoblast giant cells (TGC). In addition, accumulations of TGC occurred below Reichert's membrane. The junctional zone contained syncytial trophoblast, proliferative cellular trophoblast, glycogen cells and TGC that were situated near to the maternal blood channels. In three of the genera, TGC were also accumulated in distinct areas at the placental periphery. PAS-positive glycogen cells derived from the junctional zone invaded the decidua. Abundant maternal uNK cells with positive response to PAS, vimentin and DBA-lectin were found in the decidua. The visceral yolk sac was completely inverted and villous. CONCLUSION: The general aspect of the fetal membranes in Sigmodontinae resembled that found in other cricetid rodents. Compared to murid rodents there were larger numbers of giant cells and in some genera these were seen to congregate at the periphery of the placental disk. Glycogen cells were found to invade the decidua but we did not identify trophoblast in the walls of the deeper decidual arteries. In contrast these vessels were surrounded by large numbers of uNK cells. This survey of wild-trapped specimens from five genera is a useful starting point for the study of placentation in an important subfamily of South American rodents. We note, however, that some of these rodents can be captive bred and recommend that future studies focus on the study of time dated pregnancies. BioMed Central 2011-04-25 /pmc/articles/PMC3094283/ /pubmed/21518439 http://dx.doi.org/10.1186/1477-7827-9-55 Text en Copyright ©2011 Favaron et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Favaron, Phelipe O
Carter, Anthony M
Ambrósio, Carlos E
Morini, Adriana C
Mess, Andrea M
de Oliveira, Moacir F
Miglino, Maria A
Placentation in Sigmodontinae: a rodent taxon native to South America
title Placentation in Sigmodontinae: a rodent taxon native to South America
title_full Placentation in Sigmodontinae: a rodent taxon native to South America
title_fullStr Placentation in Sigmodontinae: a rodent taxon native to South America
title_full_unstemmed Placentation in Sigmodontinae: a rodent taxon native to South America
title_short Placentation in Sigmodontinae: a rodent taxon native to South America
title_sort placentation in sigmodontinae: a rodent taxon native to south america
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094283/
https://www.ncbi.nlm.nih.gov/pubmed/21518439
http://dx.doi.org/10.1186/1477-7827-9-55
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