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Centriole assembly and the role of Mps1: defensible or dispensable?

The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to r...

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Detalles Bibliográficos
Autores principales: Pike, Amanda N, Fisk, Harold A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094359/
https://www.ncbi.nlm.nih.gov/pubmed/21492451
http://dx.doi.org/10.1186/1747-1028-6-9
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author Pike, Amanda N
Fisk, Harold A
author_facet Pike, Amanda N
Fisk, Harold A
author_sort Pike, Amanda N
collection PubMed
description The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be both universally conserved and essential in most organisms, conservation of its originally described function in spindle pole duplication has proven controversial, and it is less clear whether Mps1 is essential for centrosome duplication outside of budding yeast. Recent studies of Mps1 have identified at least two distinct functions for Mps1 in centriole assembly, while simultaneously supporting the notion that Mps1 is dispensable for the process. However, the fact that at least one centrosomal substrate of Mps1 is conserved from yeast to humans down to the phosphorylation site, combined with evidence demonstrating the exquisite control exerted over centrosomal Mps1 levels suggest that the notion of being essential may not be the most important of distinctions.
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spelling pubmed-30943592011-05-14 Centriole assembly and the role of Mps1: defensible or dispensable? Pike, Amanda N Fisk, Harold A Cell Div Review The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be both universally conserved and essential in most organisms, conservation of its originally described function in spindle pole duplication has proven controversial, and it is less clear whether Mps1 is essential for centrosome duplication outside of budding yeast. Recent studies of Mps1 have identified at least two distinct functions for Mps1 in centriole assembly, while simultaneously supporting the notion that Mps1 is dispensable for the process. However, the fact that at least one centrosomal substrate of Mps1 is conserved from yeast to humans down to the phosphorylation site, combined with evidence demonstrating the exquisite control exerted over centrosomal Mps1 levels suggest that the notion of being essential may not be the most important of distinctions. BioMed Central 2011-04-14 /pmc/articles/PMC3094359/ /pubmed/21492451 http://dx.doi.org/10.1186/1747-1028-6-9 Text en Copyright ©2011 Pike and Fisk; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Pike, Amanda N
Fisk, Harold A
Centriole assembly and the role of Mps1: defensible or dispensable?
title Centriole assembly and the role of Mps1: defensible or dispensable?
title_full Centriole assembly and the role of Mps1: defensible or dispensable?
title_fullStr Centriole assembly and the role of Mps1: defensible or dispensable?
title_full_unstemmed Centriole assembly and the role of Mps1: defensible or dispensable?
title_short Centriole assembly and the role of Mps1: defensible or dispensable?
title_sort centriole assembly and the role of mps1: defensible or dispensable?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094359/
https://www.ncbi.nlm.nih.gov/pubmed/21492451
http://dx.doi.org/10.1186/1747-1028-6-9
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