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Paeoniae alba Radix Promotes Peripheral Nerve Regeneration
The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth asso...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094696/ https://www.ncbi.nlm.nih.gov/pubmed/19687191 http://dx.doi.org/10.1093/ecam/nep115 |
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author | Huang, Kun-Shan Lin, Jaung-Geng Lee, Han-Chung Tsai, Fuu-Jen Bau, Da-Tian Huang, Chih-Yang Yao, Chun-Hsu Chen, Yueh-Sheng |
author_facet | Huang, Kun-Shan Lin, Jaung-Geng Lee, Han-Chung Tsai, Fuu-Jen Bau, Da-Tian Huang, Chih-Yang Yao, Chun-Hsu Chen, Yueh-Sheng |
author_sort | Huang, Kun-Shan |
collection | PubMed |
description | The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats. At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml(−1) had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group (P < .05). These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve. |
format | Text |
id | pubmed-3094696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30946962011-05-20 Paeoniae alba Radix Promotes Peripheral Nerve Regeneration Huang, Kun-Shan Lin, Jaung-Geng Lee, Han-Chung Tsai, Fuu-Jen Bau, Da-Tian Huang, Chih-Yang Yao, Chun-Hsu Chen, Yueh-Sheng Evid Based Complement Alternat Med Original Article The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats. At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml(−1) had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group (P < .05). These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve. Hindawi Publishing Corporation 2011 2011-01-11 /pmc/articles/PMC3094696/ /pubmed/19687191 http://dx.doi.org/10.1093/ecam/nep115 Text en Copyright © 2011 Kun-Shan Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Huang, Kun-Shan Lin, Jaung-Geng Lee, Han-Chung Tsai, Fuu-Jen Bau, Da-Tian Huang, Chih-Yang Yao, Chun-Hsu Chen, Yueh-Sheng Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title |
Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title_full |
Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title_fullStr |
Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title_full_unstemmed |
Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title_short |
Paeoniae alba Radix Promotes Peripheral Nerve Regeneration |
title_sort | paeoniae alba radix promotes peripheral nerve regeneration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094696/ https://www.ncbi.nlm.nih.gov/pubmed/19687191 http://dx.doi.org/10.1093/ecam/nep115 |
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