Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Cross-linking and immunoprecipitation coupled with high-throughput sequencing was used to identify binding sites within 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein which when mutated causes Amyotrophic Lateral Sclerosis (ALS). Use of massively parallel sequencing and spli...

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Detalles Bibliográficos
Autores principales: Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Hutt, Kasey R., Huelga, Stephanie C., Moran, Jacqueline, Liang, Tiffany Y., Ling, Shuo-Chien, Sun, Eveline, Wancewicz, Edward, Mazur, Curt, Kordasiewicz, Holly, Sedaghat, Yalda, Donohue, John Paul, Shiue, Lily, Bennett, C. Frank, Yeo, Gene W., Cleveland, Don W.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094729/
https://www.ncbi.nlm.nih.gov/pubmed/21358643
http://dx.doi.org/10.1038/nn.2779

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