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The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly abundant chromatin-associated enzyme present in all higher eukaryotic cell nuclei, where it plays key roles in the maintenance of genomic integrity, chromatin remodeling and transcriptional control. It binds to DNA single- and double-strand breaks th...

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Detalles Bibliográficos
Autores principales:	Eustermann, Sebastian, Videler, Hortense, Yang, Ji-Chun, Cole, Paul T., Gruszka, Dominika, Veprintsev, Dmitry, Neuhaus, David
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094755/ https://www.ncbi.nlm.nih.gov/pubmed/21262234 http://dx.doi.org/10.1016/j.jmb.2011.01.034

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