Applicability of Generic Assays Based on Liquid Chromatography–Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds

Liquid chromatography–mass spectrometry (LC–MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of data in a short time frame for drug candidates. The analysis with non-optimized parameters ho...

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Detalles Bibliográficos
Autores principales: Rousu, Timo, Hokkanen, Juho, Pelkonen, Olavi R., Tolonen, Ari
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095372/
https://www.ncbi.nlm.nih.gov/pubmed/21607061
http://dx.doi.org/10.3389/fphar.2010.00010

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