Cargando…
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice
Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic agent that is frequently used in the ancient Indian medical system. We have earlier reported the reversal of diazepam-i...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095476/ https://www.ncbi.nlm.nih.gov/pubmed/21607013 http://dx.doi.org/10.1093/ecam/neq038 |
_version_ | 1782203653761794048 |
---|---|
author | Saraf, Manish Kumar Prabhakar, Sudesh Khanduja, Krishan Lal Anand, Akshay |
author_facet | Saraf, Manish Kumar Prabhakar, Sudesh Khanduja, Krishan Lal Anand, Akshay |
author_sort | Saraf, Manish Kumar |
collection | PubMed |
description | Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic agent that is frequently used in the ancient Indian medical system. We have earlier reported the reversal of diazepam-induced amnesia with B. monniera. In this study we wanted to test if scopolamine-induced impairment of spatial memory can also be ameliorated by B. monniera using water maze mouse model. The objective of study was to study the effect of B. monniera on scopolamine-induced amnesia. We employed Morris water maze scale to test the amnesic effect of scopolamine and its reversal by B. monniera. Rotarod test was conducted to screen muscle coordination activity of mice. Scopolamine significantly impaired the acquisition and retrieval of memory producing both anterograde and retrograde amnesia. Bacopa monniera extract was able to reverse both anterograde and retrograde amnesia. We propose that B. monniera's effects on cholinergic system may be helpful for developing alternative therapeutic approaches for the treatment of Alzheimer's disease. |
format | Text |
id | pubmed-3095476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30954762011-05-23 Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice Saraf, Manish Kumar Prabhakar, Sudesh Khanduja, Krishan Lal Anand, Akshay Evid Based Complement Alternat Med Original Article Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic agent that is frequently used in the ancient Indian medical system. We have earlier reported the reversal of diazepam-induced amnesia with B. monniera. In this study we wanted to test if scopolamine-induced impairment of spatial memory can also be ameliorated by B. monniera using water maze mouse model. The objective of study was to study the effect of B. monniera on scopolamine-induced amnesia. We employed Morris water maze scale to test the amnesic effect of scopolamine and its reversal by B. monniera. Rotarod test was conducted to screen muscle coordination activity of mice. Scopolamine significantly impaired the acquisition and retrieval of memory producing both anterograde and retrograde amnesia. Bacopa monniera extract was able to reverse both anterograde and retrograde amnesia. We propose that B. monniera's effects on cholinergic system may be helpful for developing alternative therapeutic approaches for the treatment of Alzheimer's disease. Hindawi Publishing Corporation 2011 2011-02-13 /pmc/articles/PMC3095476/ /pubmed/21607013 http://dx.doi.org/10.1093/ecam/neq038 Text en Copyright © 2011 Manish Kumar Saraf et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Saraf, Manish Kumar Prabhakar, Sudesh Khanduja, Krishan Lal Anand, Akshay Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title |
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title_full |
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title_fullStr |
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title_full_unstemmed |
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title_short |
Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice |
title_sort | bacopa monniera attenuates scopolamine-induced impairment of spatial memory in mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095476/ https://www.ncbi.nlm.nih.gov/pubmed/21607013 http://dx.doi.org/10.1093/ecam/neq038 |
work_keys_str_mv | AT sarafmanishkumar bacopamonnieraattenuatesscopolamineinducedimpairmentofspatialmemoryinmice AT prabhakarsudesh bacopamonnieraattenuatesscopolamineinducedimpairmentofspatialmemoryinmice AT khandujakrishanlal bacopamonnieraattenuatesscopolamineinducedimpairmentofspatialmemoryinmice AT anandakshay bacopamonnieraattenuatesscopolamineinducedimpairmentofspatialmemoryinmice |