The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats

The traditional Japanese medicine rikkunshito ameliorates the nitric oxide-associated delay in gastric emptying. Whether rikkunshito affects gastric motility associated with 5-hydroxytryptamine (serotonin: 5-HT) receptors or dopamine receptors is unknown. We examined the effects of rikkunshito on th...

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Autores principales: Tominaga, K., Kido, T., Ochi, M., Sadakane, C., Mase, A., Okazaki, H., Yamagami, H., Tanigawa, T., Watanabe, K., Watanabe, T., Fujiwara, Y., Oshitani, N., Arakawa, T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095508/
https://www.ncbi.nlm.nih.gov/pubmed/19861508
http://dx.doi.org/10.1093/ecam/nep173
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author Tominaga, K.
Kido, T.
Ochi, M.
Sadakane, C.
Mase, A.
Okazaki, H.
Yamagami, H.
Tanigawa, T.
Watanabe, K.
Watanabe, T.
Fujiwara, Y.
Oshitani, N.
Arakawa, T.
author_facet Tominaga, K.
Kido, T.
Ochi, M.
Sadakane, C.
Mase, A.
Okazaki, H.
Yamagami, H.
Tanigawa, T.
Watanabe, K.
Watanabe, T.
Fujiwara, Y.
Oshitani, N.
Arakawa, T.
author_sort Tominaga, K.
collection PubMed
description The traditional Japanese medicine rikkunshito ameliorates the nitric oxide-associated delay in gastric emptying. Whether rikkunshito affects gastric motility associated with 5-hydroxytryptamine (serotonin: 5-HT) receptors or dopamine receptors is unknown. We examined the effects of rikkunshito on the delay in gastric emptying induced by 5-HT or dopamine using the phenol red method in male Wistar rats. 5-HT (0.01–1.0 mg kg(−1), i.p.) dose dependently delayed gastric emptying, similar to the effect of the 5-HT(3) receptor agonist 1-(3-chlorophenyl) biguanide (0.01–1.0 mg kg(−1), i.p.). Dopamine also dose dependently delayed gastric emptying. The 5-HT(3) receptor antagonist ondansetron (0.04–4.0 mg kg(−1)) and rikkunshito (125–500 mg kg(−1)) significantly suppressed the delay in gastric emptying caused by 5-HT or 1-(3-chlorophenyl) biguanide. Hesperidin (the most active ingredient in rikkunshito) suppressed the 5-HT-induced delayed gastric emptying in a dose-dependent manner, the maximum effect of which was similar to that of ondansetron (0.4 mg kg(−1)). The improvement obtained by rikkunshito or ondansetron in delaying gastric emptying was completely blocked by pretreatment with atropine. Rikkunshito appears to improve delay in gastric emptying via the antagonistic action of the 5-HT(3) receptor pathway.
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spelling pubmed-30955082011-06-17 The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats Tominaga, K. Kido, T. Ochi, M. Sadakane, C. Mase, A. Okazaki, H. Yamagami, H. Tanigawa, T. Watanabe, K. Watanabe, T. Fujiwara, Y. Oshitani, N. Arakawa, T. Evid Based Complement Alternat Med Original Article The traditional Japanese medicine rikkunshito ameliorates the nitric oxide-associated delay in gastric emptying. Whether rikkunshito affects gastric motility associated with 5-hydroxytryptamine (serotonin: 5-HT) receptors or dopamine receptors is unknown. We examined the effects of rikkunshito on the delay in gastric emptying induced by 5-HT or dopamine using the phenol red method in male Wistar rats. 5-HT (0.01–1.0 mg kg(−1), i.p.) dose dependently delayed gastric emptying, similar to the effect of the 5-HT(3) receptor agonist 1-(3-chlorophenyl) biguanide (0.01–1.0 mg kg(−1), i.p.). Dopamine also dose dependently delayed gastric emptying. The 5-HT(3) receptor antagonist ondansetron (0.04–4.0 mg kg(−1)) and rikkunshito (125–500 mg kg(−1)) significantly suppressed the delay in gastric emptying caused by 5-HT or 1-(3-chlorophenyl) biguanide. Hesperidin (the most active ingredient in rikkunshito) suppressed the 5-HT-induced delayed gastric emptying in a dose-dependent manner, the maximum effect of which was similar to that of ondansetron (0.4 mg kg(−1)). The improvement obtained by rikkunshito or ondansetron in delaying gastric emptying was completely blocked by pretreatment with atropine. Rikkunshito appears to improve delay in gastric emptying via the antagonistic action of the 5-HT(3) receptor pathway. Hindawi Publishing Corporation 2011 2011-02-13 /pmc/articles/PMC3095508/ /pubmed/19861508 http://dx.doi.org/10.1093/ecam/nep173 Text en Copyright © 2011 K. Tominaga et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tominaga, K.
Kido, T.
Ochi, M.
Sadakane, C.
Mase, A.
Okazaki, H.
Yamagami, H.
Tanigawa, T.
Watanabe, K.
Watanabe, T.
Fujiwara, Y.
Oshitani, N.
Arakawa, T.
The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title_full The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title_fullStr The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title_full_unstemmed The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title_short The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats
title_sort traditional japanese medicine rikkunshito promotes gastric emptying via the antagonistic action of the 5-ht(3) receptor pathway in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095508/
https://www.ncbi.nlm.nih.gov/pubmed/19861508
http://dx.doi.org/10.1093/ecam/nep173
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