Cargando…

A 6-gene signature identifies four molecular subgroups of neuroblastoma

BACKGROUND: There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene MYCN (MNA) and low expression of the favourable marker NTRK1. Recently, mutat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abel, Frida, Dalevi, Daniel, Nethander, Maria, Jörnsten, Rebecka, De Preter, Katleen, Vermeulen, Joëlle, Stallings, Raymond, Kogner, Per, Maris, John, Nilsson, Staffan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095533/ https://www.ncbi.nlm.nih.gov/pubmed/21492432 http://dx.doi.org/10.1186/1475-2867-11-9

Ejemplares similares

ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
por: Wilzén, Annica, et al.
Publicado: (2013)

Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes
por: Thorell, Kaisa, et al.
Publicado: (2009)

Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma
por: Carén, Helena, et al.
Publicado: (2011)

The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
por: Keane, Simon, et al.
Publicado: (2021)

Tumor Development, Growth Characteristics and Spectrum of Genetic Aberrations in the TH-MYCN Mouse Model of Neuroblastoma
por: Rasmuson, Agnes, et al.
Publicado: (2012)

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
por: Decock, Anneleen, et al.
Publicado: (2012)

The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy
por: Van Roy, Nadine, et al.
Publicado: (2009)

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
por: De Preter, Katleen, et al.
Publicado: (2006)

Integrative discovery of treatments for high-risk neuroblastoma
por: Almstedt, Elin, et al.
Publicado: (2020)

Correction: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
por: De Preter, Katleen, et al.
Publicado: (2007)

Low Frequency ALK Hotspots Mutations In Neuroblastoma Tumours Detected By Ultra-deep Sequencing: Implications For ALK Inhibitor Treatment
por: Javanmardi, Niloufar, et al.
Publicado: (2019)

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome
por: Claeys, Shana, et al.
Publicado: (2017)

Meta-mining of copy number profiles of high-risk neuroblastoma tumors
por: Depuydt, Pauline, et al.
Publicado: (2018)

Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
por: Carlson, Lena-Maria, et al.
Publicado: (2013)

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
por: Rihani, Ali, et al.
Publicado: (2015)

DNA methylation-based classification and identification of renal cell carcinoma prognosis-subgroups
por: Chen, Wenbiao, et al.
Publicado: (2019)

DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups
por: Tian, Zijian, et al.
Publicado: (2020)

Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy
por: Duan, Chao, et al.
Publicado: (2018)

Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas
por: Fransson, Susanne, et al.
Publicado: (2013)

A p53 Drug Response Signature Identifies Prognostic Genes in High-Risk Neuroblastoma
por: Barbieri, Eveline, et al.
Publicado: (2013)

Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene
por: Djos, Anna, et al.
Publicado: (2013)

Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
por: Martinez-Monleon, Angela, et al.
Publicado: (2022)

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
por: Yang, Yan, et al.
Publicado: (2020)

Identification of subgroups along the glycolysis-cholesterol synthesis axis and the development of an associated prognostic risk model
por: Zhang, Enchong, et al.
Publicado: (2021)

Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL
por: Zhang, Simeng, et al.
Publicado: (2021)

Identification of four differentially methylated genes as prognostic signatures for stage I lung adenocarcinoma
por: Luo, Wei-Ming, et al.
Publicado: (2018)

Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model
por: Zhu, Qiqi, et al.
Publicado: (2013)

An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia
por: Diviney, Andrea, et al.
Publicado: (2019)

Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors
por: Olsson, Maja, et al.
Publicado: (2016)

Targeting tachykinin receptors in neuroblastoma
por: Henssen, Anton G., et al.
Publicado: (2016)

The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines
por: Vandenhaute, Elodie, et al.
Publicado: (2015)

miR-149 inhibits cell proliferation and enhances chemosensitivity by targeting CDC42 and BCL2 in neuroblastoma
por: Mao, Fengxia, et al.
Publicado: (2019)

Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2 (SSTR2) gene at 17q24
por: Abel, F, et al.
Publicado: (1999)

Fruits and vegetables intake and its subgroups are related to depression: a cross-sectional study from a developing country
por: Baharzadeh, Elham, et al.
Publicado: (2018)

No evidence for involvement of SDHD in neuroblastoma pathogenesis
por: De Preter, Katleen, et al.
Publicado: (2004)

A four-DNA methylation signature as a novel prognostic biomarker for survival of patients with gastric cancer
por: Li, Chunmei, et al.
Publicado: (2020)

PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells
por: Qi, Lei, et al.
Publicado: (2015)

MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma
por: Yu, Yongbo, et al.
Publicado: (2018)

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma
por: Uhl, Katie L., et al.
Publicado: (2018)

Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway
por: Zhang, Huan-yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3inra060lpqd78vhos2jouu4d5