New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided...

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Detalles Bibliográficos
Autores principales: Sinauridze, Elena I., Romanov, Alexey N., Gribkova, Irina V., Kondakova, Olga A., Surov, Stepan S., Gorbatenko, Aleksander S., Butylin, Andrey A., Monakov, Mikhail Yu., Bogolyubov, Alexey A., Kuznetsov, Yuryi V., Sulimov, Vladimir B., Ataullakhanov, Fazoyl I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095642/
https://www.ncbi.nlm.nih.gov/pubmed/21603576
http://dx.doi.org/10.1371/journal.pone.0019969

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