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Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published lit...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095898/ https://www.ncbi.nlm.nih.gov/pubmed/21603168 http://dx.doi.org/10.1155/2011/365683 |
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author | Díaz Angulo, Sara Szram, Joanna Welch, Jenny Cannon, Julie Cullinan, Paul |
author_facet | Díaz Angulo, Sara Szram, Joanna Welch, Jenny Cannon, Julie Cullinan, Paul |
author_sort | Díaz Angulo, Sara |
collection | PubMed |
description | Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required. |
format | Text |
id | pubmed-3095898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30958982011-05-20 Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review Díaz Angulo, Sara Szram, Joanna Welch, Jenny Cannon, Julie Cullinan, Paul J Allergy (Cairo) Review Article Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required. Hindawi Publishing Corporation 2011 2011-03-17 /pmc/articles/PMC3095898/ /pubmed/21603168 http://dx.doi.org/10.1155/2011/365683 Text en Copyright © 2011 Sara Díaz Angulo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Díaz Angulo, Sara Szram, Joanna Welch, Jenny Cannon, Julie Cullinan, Paul Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title | Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title_full | Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title_fullStr | Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title_full_unstemmed | Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title_short | Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review |
title_sort | occupational asthma in antibiotic manufacturing workers: case reports and systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095898/ https://www.ncbi.nlm.nih.gov/pubmed/21603168 http://dx.doi.org/10.1155/2011/365683 |
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