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Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review

Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published lit...

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Autores principales: Díaz Angulo, Sara, Szram, Joanna, Welch, Jenny, Cannon, Julie, Cullinan, Paul
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095898/
https://www.ncbi.nlm.nih.gov/pubmed/21603168
http://dx.doi.org/10.1155/2011/365683
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author Díaz Angulo, Sara
Szram, Joanna
Welch, Jenny
Cannon, Julie
Cullinan, Paul
author_facet Díaz Angulo, Sara
Szram, Joanna
Welch, Jenny
Cannon, Julie
Cullinan, Paul
author_sort Díaz Angulo, Sara
collection PubMed
description Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required.
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spelling pubmed-30958982011-05-20 Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review Díaz Angulo, Sara Szram, Joanna Welch, Jenny Cannon, Julie Cullinan, Paul J Allergy (Cairo) Review Article Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required. Hindawi Publishing Corporation 2011 2011-03-17 /pmc/articles/PMC3095898/ /pubmed/21603168 http://dx.doi.org/10.1155/2011/365683 Text en Copyright © 2011 Sara Díaz Angulo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Díaz Angulo, Sara
Szram, Joanna
Welch, Jenny
Cannon, Julie
Cullinan, Paul
Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title_full Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title_fullStr Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title_full_unstemmed Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title_short Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review
title_sort occupational asthma in antibiotic manufacturing workers: case reports and systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095898/
https://www.ncbi.nlm.nih.gov/pubmed/21603168
http://dx.doi.org/10.1155/2011/365683
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