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Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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PAGEPress Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096032/ https://www.ncbi.nlm.nih.gov/pubmed/21589818 http://dx.doi.org/10.4081/pr.2009.e2 |
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author | Maghbool, Maryam Maghbool, Masood Shahriari, Mehdi Karimi, Mehran |
author_facet | Maghbool, Maryam Maghbool, Masood Shahriari, Mehdi Karimi, Mehran |
author_sort | Maghbool, Maryam |
collection | PubMed |
description | Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count >150×10(9)/L) or partial (platelet count between 50 and 150×10(9)/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients. |
format | Text |
id | pubmed-3096032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30960322011-05-17 Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? Maghbool, Maryam Maghbool, Masood Shahriari, Mehdi Karimi, Mehran Pediatr Rep Article Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count >150×10(9)/L) or partial (platelet count between 50 and 150×10(9)/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients. PAGEPress Publications 2009-06-08 /pmc/articles/PMC3096032/ /pubmed/21589818 http://dx.doi.org/10.4081/pr.2009.e2 Text en ©Copyright M. Maghbool et al., 2009 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0) Licensee PAGEPress, Italy |
spellingShingle | Article Maghbool, Maryam Maghbool, Masood Shahriari, Mehdi Karimi, Mehran Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title | Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title_full | Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title_fullStr | Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title_full_unstemmed | Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title_short | Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
title_sort | does helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096032/ https://www.ncbi.nlm.nih.gov/pubmed/21589818 http://dx.doi.org/10.4081/pr.2009.e2 |
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