Cargando…

Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?

Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based...

Descripción completa

Detalles Bibliográficos
Autores principales: Maghbool, Maryam, Maghbool, Masood, Shahriari, Mehdi, Karimi, Mehran
Formato: Texto
Lenguaje:English
Publicado: PAGEPress Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096032/
https://www.ncbi.nlm.nih.gov/pubmed/21589818
http://dx.doi.org/10.4081/pr.2009.e2
_version_ 1782203704375508992
author Maghbool, Maryam
Maghbool, Masood
Shahriari, Mehdi
Karimi, Mehran
author_facet Maghbool, Maryam
Maghbool, Masood
Shahriari, Mehdi
Karimi, Mehran
author_sort Maghbool, Maryam
collection PubMed
description Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count >150×10(9)/L) or partial (platelet count between 50 and 150×10(9)/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients.
format Text
id pubmed-3096032
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-30960322011-05-17 Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? Maghbool, Maryam Maghbool, Masood Shahriari, Mehdi Karimi, Mehran Pediatr Rep Article Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10–15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count >150×10(9)/L) or partial (platelet count between 50 and 150×10(9)/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients. PAGEPress Publications 2009-06-08 /pmc/articles/PMC3096032/ /pubmed/21589818 http://dx.doi.org/10.4081/pr.2009.e2 Text en ©Copyright M. Maghbool et al., 2009 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0) Licensee PAGEPress, Italy
spellingShingle Article
Maghbool, Maryam
Maghbool, Masood
Shahriari, Mehdi
Karimi, Mehran
Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title_full Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title_fullStr Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title_full_unstemmed Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title_short Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
title_sort does helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096032/
https://www.ncbi.nlm.nih.gov/pubmed/21589818
http://dx.doi.org/10.4081/pr.2009.e2
work_keys_str_mv AT maghboolmaryam doeshelicobacterpyloriplayaroleinthepathogenesisofchildhoodchronicidiopathicthrombocytopenicpurpura
AT maghboolmasood doeshelicobacterpyloriplayaroleinthepathogenesisofchildhoodchronicidiopathicthrombocytopenicpurpura
AT shahriarimehdi doeshelicobacterpyloriplayaroleinthepathogenesisofchildhoodchronicidiopathicthrombocytopenicpurpura
AT karimimehran doeshelicobacterpyloriplayaroleinthepathogenesisofchildhoodchronicidiopathicthrombocytopenicpurpura